Oxidation-reduction potential studies: A new method in pharmacology principles,materials, and methods |
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| Affiliation: | 1. Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400044, China;2. Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400044, China;3. MaREI Centre, Environmental Research Institute, University College Cork, Cork, Ireland;4. Civil, Structural, and Environmental Engineering, School of Engineering and Architecture, University College Cork, Cork, Ireland |
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| Abstract: | ![]()
Oxidation-reduction (redox) potential measurement is not used in pharmacology at the present time. However, it represents a physicochemical parameter that may be as important as the other currently used physicochemical parameters, such as pH and pKa. Redox potential variations include conformational modifications that may influence bioavailability of drugs. We report here an original and convenient equilibrium method to determine this potential in biological fluids, especially in blood. |
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