| 吸入性损伤对小鼠肺组织细胞凋亡的影响 |
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| 引用本文： | 廖圣德,赵烨德,刘刚,李旭东. 吸入性损伤对小鼠肺组织细胞凋亡的影响[J]. 中华航海医学与高气压医学杂志, 2006, 13(2): 102-104 |
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| 作者姓名： | 廖圣德 赵烨德 刘刚 李旭东 |
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| 作者单位： | 200081,上海,解放军第四一一医院烧伤整形科 |
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| 摘 要： | 目的探讨细胞凋亡、促凋亡基因和凋亡抑制基因在吸入性损伤发生的作用及意义。方法以小鼠烟雾吸入性损伤为模型，应用RT—PCR和TUNEL技术，观察其损伤后肺组织中Bcl-2和Bax基因mRNA表达及细胞凋亡的变化。结果小鼠烟雾吸入性损伤后肺组织Bcl-2和Bax的表达增加，细胞凋亡指数升高，与对照组相比，差异有非常显著性（P〈0．01）。结论提示细胞凋亡可能参与了吸入性损伤肺组织的病理形成过程。
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| 关 键 词： | 吸入性损伤 细胞凋亡 Bcl-2基因 Bax基因 |
| 收稿时间： | 2005-12-09 |
| 修稿时间： | 2005-12-09 |
The influence of smoke inhalation injury on the apoptosis of lung tissue cells in rats |
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| ZHAO Ye-de ,LIU Gang ,et al. The influence of smoke inhalation injury on the apoptosis of lung tissue cells in rats[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2006, 13(2): 102-104 |
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| Authors: | ZHAO Ye-de LIU Gang et al |
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| Affiliation: | No. 411 Hospital of CPLA, Shanghai 200081, China |
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| Abstract: | Objective To explore the role and significance of apoptosis,pro-apoptotic genes and apoptosis suppressor genes in the pathogenesis and development of inhalation injury.Methods Smoke inhalation injury model was established in rats,and the mRNA expressions of Bcl-2,Bax,and apoptosis in the lung tissue were observed.Results The expressions of Bcl-2 and Bax,and the apoptotic index (AI) in the inhalation injury group were significantly increased,compared with the control group (P<0.01).Conclusions It is suggested that apoptosis might play an role in the pathology process of smoke inhalation injury. |
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| Keywords: | Inhalation injury Apoptosis Bcl-2 gene Bax gene |
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