| 免疫治疗在胆道恶性肿瘤中的应用进展 |
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| 引用本文： | 刘立果,张一鉴,王许安,刘颖斌. 免疫治疗在胆道恶性肿瘤中的应用进展[J]. 中华外科杂志, 2021, 0(2): 156-160 |
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| 作者姓名： | 刘立果 张一鉴 王许安 刘颖斌 |
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| 作者单位： | 上海交通大学医学院附属仁济医院胆胰外科 |
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| 基金项目： | 国家自然科学基金(31620103910);重大新药创制科技重大专项(2019ZX09301158)。 |
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| 摘 要： | 胆道恶性肿瘤主要包括胆囊癌和胆管癌,具有早期诊断率低、解剖复杂、对放化疗不敏感、预后差等特点。近年来,免疫治疗作为一种新的方法在治疗晚期恶性肿瘤过程中取得了良好效果,以免疫检查点抑制剂、过继细胞治疗、肿瘤疫苗等为代表的免疫治疗也正在胆道恶性肿瘤中进行初步探索。
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| 关 键 词： | 胆道肿瘤 免疫治疗 免疫检查点抑制剂 过继细胞治疗 肿瘤疫苗 |
Advance in immunotherapy on biliary tract cancers |
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| Liu Liguo,Zhang Yijian,Wang Xu′an,Liu Yingbin. Advance in immunotherapy on biliary tract cancers[J]. Chinese Journal of Surgery, 2021, 0(2): 156-160 |
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| Authors: | Liu Liguo Zhang Yijian Wang Xu′an Liu Yingbin |
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| Affiliation: | (Department of Biliary-Pancreatic Surgery,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Biliary Tract Disease Research,Shanghai Research Center of Biliary Tract Disease,State Key Laboratory for Oncogenes and Related Genes,Shanghai 200127,China) |
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| Abstract: | Biliary tract cancers(BTC),including gallbladder cancer and cholangiocarcinoma,has the characteristics of low early diagnosis rate,complex anatomy,insensitivity to radiotherapy and chemotherapy,and poor prognosis.In recent years,immunotherapy as a new method,has made great progress in the treatment of advanced malignant tumors.Immunotherapy is gradually applied in the treatment of BTC,such as inhibitory agents targeting the immune checkpoint receptor pathway,adoptive immunotherapy and tumor vaccines. |
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| Keywords: | Biliary neoplasms Immunotherapy Checkpoint receptor inhibitors Adoptive cell therapy Tumor vaccine |
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