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| The role of synphilin-1 in the pathogenesis of Parkinson’s disease | |
| 作者姓名： | Rui ZHENG Hai-Yan ZHOU Sheng-Di CHEN Department of Neurology and Institute of Neurology Shanghai Jiaotong University School of Medicine Shanghai 200025 China |
| 作者单位： | Rui ZHENG，Hai-Yan ZHOU，Sheng-Di CHEN Department of Neurology and Institute of Neurology，Shanghai Jiaotong University School of Medicine，Shanghai 200025，China |
| 摘 要： | 1 Introduction Parkinson’s disease (PD) is the second most common neurological disorder to affect approximate 0.2% of overall population and 2% of those over the age of 65. The disease is characterized by a triad of cardinal symptoms, including bradykinesia (slowed movement), resting tremor, and rigidity. Progressive degeneration of the dopaminergic (DAergic) neurons which are mostly located in the sub- stantia nigra pars compacta (SNpc), and the formation of eosinophilic inclusions known a… |
| 关 键 词： | synphlin-1 Parkinson’s disease α-synuclein |
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