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Clinical profile and treatment outcome of febrile infection-related epilepsy syndrome in South Indian children
Authors:Sandeep B. Patil  Arun Grace Roy  Kollencheri Puthenveettil Vinayan
Affiliation:Division of Pediatric Neurology, Department of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
Abstract:
Purpose:To describe the clinical features and outcome of febrile infection-related epilepsy syndrome (FIRES), a catastrophic epileptic encephalopathy, in a cohort of South Indian children.Significance:This study reports one of the largest single center cohorts from India, with an adverse long-term developmental and seizure outcome. The duration and severity of seizures in the acute period correlated directly with the short-term and long-term clinical outcomes. There is an urgent need for developing new effective therapeutic strategies to treat this acute catastrophic epileptic syndrome.
Keywords:Encephalopathy   febrile infection   status epilepticus
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