Comparative analysis of effects from prolonged peripheral and intracerebral administrations of angiotensin II in rats

Variations in arterial pressure and food and water consumption were studied in rats during and after their prolonged continuous exposure to angiotensin II using osmotic minipumps. Subcutaneously administered angiotensin-II (300 μg over 7 days) induced long-lasting hypertension followed by hypotension. Angiotensin-II administered into a lateral cerebral ventricle (3 μg over the same period) led to a significant fall in arterial pressure. The peripheral and intracerebral angiotensin-II administrations were both accompanied by increased water consumption. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N^no 10, pp. 352–354, October, 1994 Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences