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阿德福韦酯联合柴胡愈肝汤对慢性乙型肝炎的疗效观察
引用本文:周兴华,钟森. 阿德福韦酯联合柴胡愈肝汤对慢性乙型肝炎的疗效观察[J]. 泸州医学院学报, 2011, 34(6): 690-692
作者姓名:周兴华  钟森
作者单位:成都中医药大学第三附属医院中医科,四川成都,610075
摘    要:
目的:观察阿德福韦酯联合柴胡愈肝汤治疗慢性乙型肝炎的临床疗效。方法:将符合诊断标准的慢性乙型肝炎患者47例,随机分为对照组和治疗组,对照组给予阿德福韦酯治疗,治疗组在对照组治疗基础上加用自拟柴胡愈肝汤治疗。观察两组用药12个月和停药后6个月乙肝两对半、HBV-DNA、ALT、TBIL以及药物不良反应,并进行统计分析。结果:两组近期HBV—DNA转阴率无明显差异(P〉0.05),但治疗组HbeAg的转阴率和肝功能的复常率明显提高(P〈0.05)。同时停药6个月后随访发现,两组均出现HBV—DNA水平反弹,但治疗组HBV-DNA水平较对照组低(P〈0.05),而且仍然保持较高的HBeAg转阴率,HBeAb阳转率也有所增加。结论:治疗组在对照组治疗基础上加用柴胡愈肝汤治疗及治疗后效应明显优于对照组。

关 键 词:阿德福韦酯  柴胡愈肝汤/治疗  慢性乙型肝炎

THERAPEUTIC EFFECT OF ADEFOVIR DIPIVOXIL COMBINED WITH CHAIHUYUGAN DECOCTION TREATING CHRONIC HEPATITIS B
Affiliation:Zhou Xinghua,et al Department of TCM,the Third’s Affilidte Hospital of Chengdu University of Traditional Chinese Medicine
Abstract:
Objective: To survey the therapeutic effect of adefovir dipivoxil combined with Chaihuyugan decoction treating chronic hepatitis B. Methods: 47 patients with chronic hepatitis B were randomly devided into control group, treating with adefovir dipivoxil, and treatment group, treating with adefovir dipivoxil combined with Chaihuyugan decoction HBV M, HBV-DNA, ALT, TBIL, and adverse reactions were observed after 12 month of treatment and 6 month after stopping the treatment,and statistically analyzed.Results: The HBV-DNA negative rate of the two groups were not significantly different (P〉0.05), yet the HbeAg negative rate and liver function recovery rate of the treatment group were significantly higher than that of control group(P〈0.05). Analysis of data collected 6 months after stopping treating, showed that the HBV-DNA level rebounced, yet the HBV-DNA level of treatment group was still lower than that of control group (P〈0.05), and the treatment group maintainde relatively high HbeAg positive rate, and got a little increase in HbeAb positive rate. Conclusion: The treatment group has a significantly better effect than the control group when adding Chaihuyugan decoction to adefovir dipivoxil.
Keywords:Adefovir dipivoxil Chaihuyugantang decoction  Chronic hepatitis B
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