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| 正交试验筛选复方盐酸萘替芬乳膏处方 | |
| 引用本文： | 刘葵. 正交试验筛选复方盐酸萘替芬乳膏处方[J]. 中国药房, 2005, 16(9): 660-662 |
| 作者姓名： | 刘葵 |
| 作者单位： | 重庆市药剂学校,重庆市,400030 |
| 摘 要： | 目的筛选复方盐酸萘替芬乳膏的最佳处方并考察其成品的稳定性。方法以十六醇、十八醇、S-40和十二烷基硫酸钠用量为可变因素,采用正交试验设计,选用L9(34)表进行试验。结果最优处方组成为十六醇4%、十八醇2%、S-406%和十二烷基硫酸钠0.1%,由此制备的成品稳定性好。结论按优化处方及方法制备的乳膏符合《中国药典》规定。 |
| 关 键 词： | 复方盐酸萘替芬乳膏 萘替芬 酮康唑 正交试验设计 |
| 文章编号： | 1001-0408(2005)09-0660-03 |
| 修稿时间： | 2004-10-12 |
To Optimize Formula for the Compound Naftifine Hydrochloride Cream by the Orthogonal Experimental |
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| LIU Kui. To Optimize Formula for the Compound Naftifine Hydrochloride Cream by the Orthogonal Experimental[J]. China Pharmacy, 2005, 16(9): 660-662 | |
| Authors: | LIU Kui |
| Abstract: | OBJECTIVE:To optimize formula for the compound naftifine hydrochloride cream and to study the stability of its finished products.METHOD:The dosage of the hexadecanol,octadecanol,S-40and sodium dodecyl sulfate was taken as variable factor,the orthogonal experimental design method was adopted and L 9 (3 4 )table was chosen for the experiment.RE-SULTS:The optimized formula is composed of4%of hexadecanol,2%of octadecanol,6%of S-40and0.1%of sodium do-decyl sulfate,from which the finished products manufactured had good stability.CONCLUSION:The cream prepared from this optimized formula and method can meet the specification stated in Chinese Pharmacopoeia. |
| Keywords: | Compound naftifine hydrochloride cream Naftifine Ketoconazole Orthogonal experimental design |
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