T-钙黏蛋白在乳腺癌中表达及其与预后关系

目的：探讨乳腺癌患者T-钙黏蛋白表达情况与乳腺癌预后相关性。方法乳腺浸润性癌（浸润性小叶癌除外）患者280例，根据T-钙黏蛋白表达分为T-钙黏蛋白表达阴性组与阳性组，分析T-钙黏蛋白在乳腺癌中表达情况与患者不同临床、病理特点及其预后。统计学分析应用SPSS 13．0软件，计数资料采用χ2检验以及Fisher精确概率法，采用Log Rank法检测乳腺癌中T-钙黏蛋白表达情况对乳腺癌5年生存率以及5年无瘤生存率的影响， P ＜0．05为差异有统计学意义。结果 T-钙黏蛋白表达阴性组与阳性组中，年龄、肿瘤直径、病理分级、病理类型、有无绝经、有无家族史等，差异均无统计学意义（P＞0．05）。 T-钙黏蛋白表达阴性组发生淋巴结转移、淋巴管浸润及临床分期Ⅲ期比例（65．2％、37．5％、23．2％）高于 T-钙黏蛋白阳性组（41．1％、13．1％、6．0％），χ2＝15．62、22．70、17．87， P＜0．05，差异有统计学意义，T-钙黏蛋白阴性患者较T-钙黏蛋白阳性患者术后生存率及无瘤生存率均低（Log Rank＝13．629，P＜0．01；Log Rank＝22．362，P＜0．01），差异有统计学意义。结论 T-钙黏蛋白表达与乳腺癌多种临床病理特点有相关性，T-钙黏蛋白表达阴性患者预后差。

Expression and predictive value of prognosis of T-cadherin in breast cancer

Objective To investigate the correlation between the expression of T-cadherin and the prognosis of patients with breast cancer . Methods We investigated a consecutive series of 280 patients with sporadic invasive breast carcinoma , except for invasive lobular carcinoma .Based on the pathological results of immunohistochemistry , the 280 patients were divided into 2 groups：negative group and Ppositive group.Clinical data including the expression of T-cadherin, clinicopathological features and prognosis were analyzed using the chi-square test and Fisher ’ s exact test using SPSS 13.0 software.The impact of the expression of T-cadher on the 5-year survival rate and the 5-year disease-free survival rate of breast cancer measured by the Log-rank test （ P〉0.05 ） was considered statistically significant . Results Compared with the T-cadherin negative group , no significant difference was observed , in age, tumor size, pathological grade, pathological type, menostasis and family history（P＆gt;0.05）in the positive group.In the negative group, lymph node metastasis, lymphatic vessel invasion and stage Ⅲ（65.2%, 37.5% and 23.2%respectively）were seen more frequentlty than in the positive group （41.1%, 13.1%and 6.0%respectively;χ2 =15.62,χ2 =22.70 and χ2 =17.87） （P〈0.05）.The survival rate of the T-cadherin negative group was poorer than that of the T-cadherin positive group （ Log-rank test=13.629, P〉0.01; Log-rank test=22.362, P〉0.01）. Conclusion There is a close correlation between the expression of T-cadherin with clinicopathological features and the prognosis of breast cancer . Patients with negative expression of T-cadherin in breast cancer would have a worse prognosis .