脑梗死患者颈动脉内膜中层增厚的影响因素分析

目的探讨脑梗死患者颈动脉内膜中层增厚(CIMT)的传统影响因素,及高尿酸血症对CIMT的影响。方法回顾性调查脑梗死患者350例。记录患者一般资料,测定患者外周血尿酸水平,用颈动脉超声检查内膜中层厚度,并对影响内膜中层厚度的因素进行统计分析。结果高尿酸血症64例(18.3%),无高尿酸血症286例(81.7%)。单因素分析发现吸烟、糖尿病、既往脑卒中史、年龄与颈动脉内膜中层增厚显著相关(P0.01)。性别、高血压、低密度脂蛋白胆固醇升高、高尿酸血症与颈动脉内膜中层增厚相关(P0.05)。多因素Logistic回归分析示年龄、糖尿病、高尿酸血症与颈动脉内膜中层增厚相关(P0.05)。吸烟与颈动脉内膜中层增厚显著相关(P0.01)。结论除传统危险因素外,高尿酸血症是影响脑梗死患者颈动脉内膜中层增厚的危险因素。

Analysis of risk factors for increased carotid intima-media thickness in patients with cerebral infarction

Objective To investigate the traditional risk factors for increased carotid intima-media thickness （CIMT） in patients withcerebral infarction and the association of hyperuricemia with increased CIMT. Methods A total of 350 patients with cerebral infarctionwere retrospectively investigated. The general data of patients were recorded. The levels of uric acid in peripheral blood were meas-ured, and CIMT was determined by carotid ultrasound. The risk factors for increased CIMT were determined by multivariate logistic re-gression analysis. Results Of 350 patients, 64（ 18.3% ） had hyperuricemia, and 286（81.7% ） had no hyperuricemia. The univariate analysis showed that smoking, diabetes, history of stroke, and age were significantly associated with increased CIMT （P 〈 0.01 ） ;sex, hypertension, elevated level of low-density lipoprotein cholesterol, and hyperuricemia were associated with increased CIMT （P 〈0.05 ）. The multivariate logistic regression analysis showed that age, diabetes, and hyperuricemia were associated with increased CIMT（ P 〈 0.05 ） ; smoking was significantly associated with increased CIMT （P 〈 0.01 ）. Conclusions In addition to traditional risk factors, hyperuricemia is a risk factor for increased CIMT in patients with cerebral infarction.