| 重症急性胰腺炎大鼠促炎细胞因子的变化及维拉帕米干预效应的研究 |
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| 引用本文： | 王淑君,陈由达,岑光力,杨建毓. 重症急性胰腺炎大鼠促炎细胞因子的变化及维拉帕米干预效应的研究[J]. 现代实用医学, 2009, 21(10): 1053-1055 |
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| 作者姓名： | 王淑君 陈由达 岑光力 杨建毓 |
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| 作者单位： | 浙江省慈溪市人民医院,浙江慈溪,315300;浙江省慈溪市人民医院,浙江慈溪,315300;浙江省慈溪市人民医院,浙江慈溪,315300;浙江省慈溪市人民医院,浙江慈溪,315300 |
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| 摘 要： | 目的探讨大鼠重症急性胰腺炎（SAP）时血清促炎细胞因子的变化及维拉帕米治疗作用。方法雄性SD大鼠90只,随机分为A组（假手术组）、B组（SAP组）和C组（维拉帕米治疗组）,每组各30只,采用改良Ahos逆行胰胆管穿刺注射法制备SAP模型,各组于术后6 h处死大鼠、测血清IL-1、IL-6和TNF-含量。结果SAP大鼠血清IL-1、IL-6和TNF-的含量较假手术组均显著升高（〈0.01）;维拉帕米治疗组促炎细胞因子水平较SAP组显著下降〈0.05或〈0.01）。结论SAP时血清中促炎细胞因子含量升高,钙通道阻滞剂维拉帕米可抑制SAP时促炎细胞因子的产生和释放,减轻胰腺组织的损害。
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| 关 键 词： | 胰腺炎 急性 细胞因子类 维拉帕米 |
Alteration of inflammatory cytokines of severe acute pancreatitis and therapeutic effects of verapamil |
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| Affiliation: | WANG Shujun, CHEN Youda, Cen Guangli, et al. ( Cixi Municipal People＇s Hospital, Cixi 315300, Zhejiang, China). |
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| Abstract: | Objective To evaluate the alteration of inflammatory cytokine during sere acute pancreatitis（SAP） and the therapeutic effects of verapamil in rats.Methods A total of 90 SD male rats were randomly divided into Group A（sham-operative group）,Group B（SAP group） and Group C（SAP treated with verapamil）.The model of rat SAP induced by amend Aho＇s converse pancreas bile duct puncture injection.All rats were killed at 6 hours after operation.Blood samples were taken for measurement of IL-1,IL-6 and TNF-.Results In SAP group the levels of IL-1,IL-6 and TNF-were significantly increased compared with those of sham-operative group（〈0.01）.In SAP with verapamil therapy group,the levels of IL-1,IL-6 and TNF-in serumwere significantly lower than those of SAP group（〈0.05 or 〈0.01）.Conclusion Inflmanatory cytokines,IL-1,IL-6 and TNF-are increased remarkably in SAP.Verapamil can reduce the level of serum IL-1,IL-6 and TNF-and the dam-age to pancreatic tissue. |
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| Keywords: | Pancretitis acute Cytokines Verapamil |
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