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Bone loss during oestriol therapy in postmenopausal women
Authors:R. Lindsay   D. M. Hart   A. Maclean   J. Garwood   A. C. Clark  A. Kraszewski
Affiliation:

a Department of Medicine, Western Infirmary, Glasgow GII 6MT, Scotland

b Departments of Obstetrics and Gynaecology, Western Infirmary and Stobhill Hospital, Glasgow GI 1 6MT, Scotland

Abstract:In contrast to all other oestrogens examined thus far oestriol hemisuccinate (12 mg/day) did not prevent bone loss in 28 postmenopausal women. The average bone loss, however, was somewhat less than expected from placebo studies, while the bone loss achieved by a group taking 4–6 mg/day was equal to that achieved by previous placebo groups. To be an effective agent for prevention of post-menopausal osteoporosis oestriol would have to be prescribed in daily doses considerably in excess of 12 mg.
Keywords:Oestriol   Bone loss   Osteoporosis   Postmenopause
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