脑脊液中的脑新肽和电针镇痛

<正> 脑新肽是我们从人脑和兔脑中分离得到的一个阿片样肽,它的结构式为Asn-Ala-Gly-Ala。它在大白鼠脑阿片受体上,能和~3H-纳洛酮竞争。用小白鼠脑室注射,家兔中央灰质微量注射和耳静脉给药等实验检定结果,表明脑新肽有明显的镇痛作用。脑新肽和镇痛有关,但是否和针刺镇痛有关,这是需要阐明的一个问题,为此我们进行了下列四个方面的实验: 1.针刺前后人脑脊液中脑新肽含量的变化。 2.针刺镇痛过程中,家兔脑脊液中脑肽含量的动态变化情况。 3.针刺镇痛前后,家兔中央灰质灌流液中脑新肽含量的变化。 4.家兔耳静脉注射脑新肽时,脑脊液中脑新肽含量的动态变化情况。

CSF NAGA PEPTIDE AND ELECTRO-ACUPUNCTURE ANALGESIA

We have recently identified a new small peptide from human brain, It is a tetrapeptide with the structure of Asn-Ala-Gly-Ala, which has been termed "Naga Peptide". It shows potent analgesic effect in rabbit when injected into brain ventricle, central grey or venous. This analgesic effect can be antagonized by naloxone, It is assumed to be mediated by morphine receptors. The content of Naga peptide in human and rabbit CSF were increased markedly after electro-acupuncture, and the pain threshold was also incre- ased markedly at the same time. The increament of Naga was parallel to the rise of pain threshold. The amount of Naga peptide in CSF was increased markedly after in- jection of Naga intravenously, and the pain threshold of the rabbit was also increased markedly at the same time. The increment of Naga in CSF was parallel to the rise of pain threshold. These results show that Naga peptide may be one of the endogenous opioid peptide and related to the acupuncture.