| 瑞芬太尼预处理对脑缺血/再灌注大鼠脑组织MDA含量和SOD活性的影响 |
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| 引用本文： | 贾丽玲,曹定睿,张维智,李岩,范兴君.瑞芬太尼预处理对脑缺血/再灌注大鼠脑组织MDA含量和SOD活性的影响[J].中国医药指南,2010,8(5):27-29. |
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| 作者姓名： | 贾丽玲 曹定睿 张维智 李岩 范兴君 |
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| 作者单位： | 山西医科大学第一医院麻醉科,030001 |
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| 摘 要： | 目的观察瑞芬太尼预处理对脑缺血/再灌注(I/R)大鼠丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响,以探讨其脑保护作用的机制。方法成年Wistar大鼠54只随机分为3组:假手术(Sham)组、缺血/再灌注(IR)组和瑞芬太尼预处理(Rem)组,每组18只。采用大鼠4条血管阻断方法制备大鼠全脑I/R模型,各组在大鼠脑缺血15min后,设再灌注6、12、24h组,相应时间点检测各组脑组织MDA含量和SOD活性,光镜下观察脑组织病理变化。结果与Sham组比较,IR组MDA含量明显升高,SOD活性明显降低(P均<0.05),与IR组比较,Rem组可显著减少大鼠脑I/R损伤后MDA含量,提高SOD活性(P均<0.05)。结论瑞芬太尼预处理对大鼠脑I/R损伤有一定的保护作用,其机制可能与抑制自由基损伤有关。
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| 关 键 词： | 脑缺血/再灌注 丙二醛 超氧化物歧化酶 瑞芬太尼 |
Effects of Remifentanil Pretreatment on the Brain Tissue MDA Concentration and SOD Activity in Rats induced by Cerebral Ischemia-reperfusion |
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| JIA L-iling,CAO Ding-rui,ZHANG Wei-zhi,LI Yan,FAN Xing-jun.Effects of Remifentanil Pretreatment on the Brain Tissue MDA Concentration and SOD Activity in Rats induced by Cerebral Ischemia-reperfusion[J].Guide of China Medicine,2010,8(5):27-29. |
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| Authors: | JIA L-iling CAO Ding-rui ZHANG Wei-zhi LI Yan FAN Xing-jun |
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| Institution: | JIA L-iling,CAO Ding-rui,ZHANG Wei-zhi,LI Yan,FAN Xing-jun (DAN WEI) |
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| Abstract: | Objective To observe the effects of remifentanil pretreatment on the brain tissue malondialdehyde(MDA)concentration and superoxide dismutase(SOD)activity in rats induced by cerebral ischemia-reperfusion(CIR) so as to investigate cerebral protection mechanism of remifentanil. Methods A total of 54 adult male Wistar rats were randomly divided into three groups(n=18 each): sham operation group(Sham), ischemia-reperfusion group (IR), and remifentanil pretreatment group(Rem). Four-vessel occlusion was used to es... |
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| Keywords: | Cerebral ischemia-reperfusion Malondialdehyde Super oxide dismutase Remifentanil |
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