肝细胞肝癌的发病机制与治疗进展

全球肝细胞肝癌(HCC)的疾病负担正逐年增加。根据临床和组织病理特征,HCC可分为增生型和非增生型2类。HCC的发生发展与遗传和表观遗传改变密切相关,然而其发病机制尚不明确。CT/MRI是临床上常用的HCC影像学诊断方法。巴塞罗那临床肝癌分期系统是目前使用最为广泛的分期系统。HCC的治疗手段包括外科手术、肝移植、消融治疗、经动脉疗法和全身疗法。本文将着重阐述HCC发病机制和治疗方面的研究进展。

Pathogenesis and treatment progress of hepatocellular carcinoma

The global disease burden of hepatocellular carcinoma(HCC)is increasing gradually.HCC can be categorized into proliferation and non-proliferation classes.The occurrence and development of HCC are closely associated with both genetic and epigenetic changes.However,the underlying mechanisms remain unclear.CT/MRI is the most commonly used imaging modality for diagnosis of HCC.Barcelona clinic liver cancer staging system is widely used to stage HCC worldwide.The treatment options of HCC include surgery,liver transplantation,radiofrequency ablation,transcatheter arterial chemoembolization and systematic therapy.This review will focus on the progress in mechanisms and treatments of HCC.