The modulatory role of dendritic cell-T cell cross-talk in breast cancer: Challenges and prospects |
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| Affiliation: | 1. Department of Medical Biotechnology, Arak University of Medical Sciences, Arak, Iran;2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Drug Science and Technology, Turin University, Corso Raffaello 30, 10125, Torino, Italy;2. Akdeniz University Faculty of Medicine Department of Biophysics, Antalya, Turkey;1. Department of Dermatology, The First Medical Center of PLA General Hospital, Beijing, China;2. Department of Dermatology, The First Affiliated Hospital of Qiqihar Medical College, Qiqihar City, Heilongjiang Province, China;3. Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya City, Hainan Province, China;1. Department of Pediatric Surgery and Urology, Medical University of Bialystok, Bialystok, Poland;2. Department of Neurosurgery, Medical University of Bialystok, Bialystok, Poland;3. Department of Biophysics, Medical University of Bialystok, Bialystok, Poland;4. Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland;5. Department of Invasive Neurology, Medical University of Bialystok, Bialystok, Poland;1. Department of Nephrology, Dialysis and Internal Diseases, Medical University of Warsaw, Warsaw, Poland;2. Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, Warsaw, Poland;3. Department of General, Liver and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland;4. Department of Medical Informatics and Telemedicine, Medical University of Warsaw, Warsaw, Poland;1. Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan;2. Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan;3. Department of Internal Medicine, Matsumoto Dental University, Shiojiri, Japan;1. Department of Hematology, Medical University of Bialystok, Bialystok, Poland;2. Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland;3. Department of Experimental Allergology and Immunology, Medical University of Bialystok, Bialystok, Poland |
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| Abstract: | Antigen recognition and presentation are highlighted as the first steps in developing specialized antigen responses. Dendritic cells (DCs) are outstanding professional antigen-presenting cells (APCs) responsible for priming cellular immunity in pathological states, including cancer. However, the diminished or repressed function of DCs is thought to be a substantial mechanism through which tumors escape from the immune system. In this regard, DCs obtained from breast cancer (BC) patients represent a notably weakened potency to encourage specific T-cell responses. Additionally, impaired DC-T-cell cross-talk in BC facilitates the immune evade of cancer cells and is connected with tumor advancement, immune tolerance, and adverse prognosis for patients. In this review we aim to highlight the available knowledge on DC-T-cell interactions in BC aggressiveness and show its therapeutic potential in BC treatment. |
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| Keywords: | Breast cancer Immune surveillance T lymphocyte Dendritic cell Immunotherapy |
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