大鼠应激性溃疡发病机制及其防治方法的研究

为进一步了解应激性溃疡的发病机制，寻找更有效的治疗方法。以冷束缚法制成大鼠应激性溃疡动物模型。将其分成对照组、治疗Ａ组（西米替丁组）、治疗Ｂ组（东莨菪碱组）和治疗Ｃ组（西米替丁＋东莨菪碱组），通过溃疡指教、光镜与电镜观察各组病理组织学变化。结果：治疗Ｃ组防治效果优于治疗Ａ组及Ｂ组。作者认为：在应激状态下，胃粘膜局部血循环障碍与胃内ｐＨ过低是导致损伤的重要始动因素；综合使用抑酸与促进血循环的防治方法，其效果明显优于单纯抑酸方法。

Experimental researches on pathogenic mechanisms,prevention,and therapy of stress ulceration in rats.

In order to further understand pathogenic mecha-nism of stress ulceration and explore a more e ffectivetherapy,the aninal model of stress ulceration was madein rats which were divided into control group,treatmentgroup A(with cimetidine ), treatment group B ( withscopolamine),and treatment group C ( with cimetidineplus scopolamine).By means of the measurement of ul-cerative index, observation of the pathophysiologicchanges under light microscope and eletronmicroscopeand ultramicrohistology, we found that the curative of-fect of treatment group C was better than treatmentgroup A and B. It is considered that, under stress condi-tions, the disturbance of local blood circulation of thegastric mucosa and the extremly lowered intragastric pHare the important primary factors for inducing the in-jury.So that the curative effects by both inhibiting acidand promoting bloor circulation sinthetically are signifi-cantly bigher than by only inhibiting acid oniy. For thisreason, the combined use of antacids and promotingblood circulation is superior to the use of antacids alone.