2014—2016年辽宁省肿瘤医院抗生素类抗肿瘤药的使用情况分析

目的 分析2014—2016年辽宁省肿瘤医院抗生素类抗肿瘤药物的使用情况,为临床合理应用抗肿瘤药物提供参考.方法 对2014—2016年辽宁省肿瘤医院抗生素类抗肿瘤药物的使用金额、用药频度(DDDs)、日均费用(DDC)及药品排序比(B/A)进行统计与分析.结果 2014—2016年抗生素类抗肿瘤药物的总使用金额和DDDs未出现逐年增长的趋势.吡柔比星的使用金额逐年递增.表柔比星、多柔比星脂质体、多柔比星使用金额逐年递减.从排序来看,表柔比星、吡柔比星与多柔比星脂质体的使用金额连续3年排前3位.表柔比星与吡柔比星的DDDs排名持续居于前2位.抗生素类抗肿瘤药物的DDC及其排序相对稳定,多柔比星脂质体的DDC持续居于首位.大部分抗生素类抗肿瘤药物的B/A值接近于1.00.结论 辽宁省肿瘤医院抗生素类抗肿瘤药物使用基本合理,符合安全、有效、经济、方便的原则.

Analysis on the usage of antitumor antibiotics in Liaoning Cancer Hospital and Institute from 2014 to 2016

Objective To analyze the usage of antitumor antibiotics in Liaoning Cancer Hospital and Institute, and to provide reference for rational use of antitumor antibiotics. Methods The utilization information of antitumor antibiotics in Liaoning Cancer Hospital and Institute from 2014 to 2016 was extracted, and the consumption sum, defined daily doses (DDDs), defined daily cost (DDC), and drug sequence ratio (B/A) were analyzed statistically. Results From 2014 to 2016, the total consumption sums and DDDs of antitumor antibiotics were not increasing year by year. The consumption sums of pirarubicin increased year by year, while the consumption sums of epirubicin, liposomal doxorubicin, and doxorubicin decreased. From the terms of sequences, epirubicin, liposomal doxorubicin, and pirarubicin ranked the top 3 for three years. DDDs of epirubicin and pirarubicin ranked the top 2. DDC and sequences of antitumor antibiotics were relatively stable. B/A of most antitumor antibiotics were close to 1.00.Conclusion The utilization of antitumor antibiotics in Liaoning Cancer Hospital and Institute is reasonable on the whole, according with the principle of safety, effectiveness, economy, and convenience.