| 基于整合药理学的当归抗动脉粥样硬化的作用机制研究 |
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| 引用本文： | 方欢乐,张慧,陶炎炎,李瑶窈,陈衍斌.基于整合药理学的当归抗动脉粥样硬化的作用机制研究[J].实用药物与临床,2021,24(2):122-127. |
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| 作者姓名： | 方欢乐 张慧 陶炎炎 李瑶窈 陈衍斌 |
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| 作者单位： | 西安培华学院医学院,陕西 西安710125;陕西步长制药有限公司科研部,陕西 西安710075 |
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| 基金项目： | 陕西省重点研发计划项目(S2018-YF-YBSF-0010);陕西省大学生创新创业项目(S201911400012);咸阳市重大科技专项计划项目(2018K01-47)。 |
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| 摘 要： | 目的 基于整合药理学,研究当归抗动脉粥样硬化(Atherosderosis,AS)的作用机制.方法 借助中药整合药理学平台(TCMIP V2.0),预测分析当归抗动脉粥样硬化的机制及其药效物质基础.结果 当归抗动脉粥样硬化的17种有效成分,直接或间接作用于PPARG(过氧化酶体增殖物激活受体)、APOE(载脂蛋白E)、...
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| 关 键 词： | 当归 动脉粥样硬化 网络药理学 物质基础 分子机制 |
Study on the anti-atherosclerosis mechanism of Angelica based on integrated pharmacology |
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| FANG Huan-le,ZHANG Hui,TAO Yan-yan,LI Yao-yao,CHEN Yan-bin.Study on the anti-atherosclerosis mechanism of Angelica based on integrated pharmacology[J].Practical Pharmacy and Clinical Remedies,2021,24(2):122-127. |
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| Authors: | FANG Huan-le ZHANG Hui TAO Yan-yan LI Yao-yao CHEN Yan-bin |
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| Institution: | (Medical College of Xi′an Peihua University,Xi′an 710125,China;Scientific Research Department of Shaanxi Step Pharmaceutical Co.,Ltd,Xi′an 710075,China) |
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| Abstract: | Objective To study the anti-atherosclerosis(AS)mechanism of Angelica based on integrated pharmacology.Methods With TCMIP V2.0,the mechanism of anti-atherosclerotic effect of Angelica sinensis was predicted and analyzed.Results The 17 active components of Angelica had direct or indirect effects on twenty-six key drug targets,including PPARG,apoE,LCAT,CCL2,MMP9 and MTTP involving ten major regulatory pathways,such as cholesterol transmembrane transportation,cholesterol ester metabolism,inflammatory response,lipid oxidation modification,and PPARαactive gene expression.Conclusion It can be predicted that some organic acids and volatile oil components in Angelica can act on inflammation and lipid metabolism pathway through PPARG and MTTP to fight against AS. |
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| Keywords: | Angelica Atherosclerosis Network pharmacology Material basis Molecular mechanism |
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