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Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis
Authors:Yun Lan  Jason T. Lam  Gilman K.H. Siu  Wing Cheong Yam  A. James Mason  Jenny K.W. Lam
Affiliation:1. Department of Pharmacology & Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong Special Administrative Region;2. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region;3. Department of Health Technology and Informatics, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region;4. Institute of Pharmaceutical Science, King''s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom;1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;2. Task Applied Science, Bellville, Cape Town, South Africa;3. MRC Centre for Molecular and Cellular Biology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;4. Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa;5. Department of Statistics, Faculty of Natural Sciences, University of the Western Cape, Cape Town, South Africa;1. Department of Pharmacology & Pharmacy, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region;2. Faculty of Pharmacy, The University of Sydney, Australia;3. Institute of Pharmaceutical Science, King’s College London, United Kingdom;3. Institute of Pharmaceutical Science, King''s College London, 150 Stamford Street, London SE1 9NH, United Kingdom;4. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China;5. Malaria Laboratory, Department of Immunobiology, Guy''s, King''s College, and St. Thomas'' Hospitals'' School of Medicine, Borough Wing, Guy''s Hospital, Great Maze Pond, London SE1 9RT, United Kingdom;6. Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Pokfulam Road, Hong Kong, China, and Centre for Biomolecular Spectroscopy and Randall Division of Cell and Molecular Biophysics;1. Medical Research Unit–Zacatecas, Mexican Social Security Institute, Zacatecas, Mexico;2. Department of Experimental Pathology, National Institute of Medical Sciences and Nutrition ‘Salvador Zubirán’, Mexico City, Mexico;3. University of Medicine and Dentistry, New Jersey (UMDNJ)–School of Public Health, Department of Environmental and Occupational Health, Center for Global Public Health, Piscataway, NJ, USA;4. Department of Immunology, School of Medicine, Autonomous University of San Luis Potosi, San Luis Potosi, Mexico;5. Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Research Station, Vancouver, BC, Canada;1. Post Doctoral Fellow, Centre for Biomedical Informatics, National Institute for Research in Tuberculosis, India;2. Project students, Centre for Biomedical Informatics, National Institute for Research in Tuberculosis, India;3. Scientist B, Department of Bacteriology, National Institute for Research in Tuberculosis, India;4. Technical Officer, Department of Bacteriology, National Institute for Research in Tuberculosis, India;5. Technical Assistant, Department of Bacteriology, National Institute for Research in Tuberculosis, India;6. Scientist E, Division of Clinical Research, National Institute for Research in Tuberculosis, India
Abstract:
Keywords:Tuberculosis  Multi-drug resistant  Antimicrobial peptides  THP-1  Isoniazid  Clinical isolates
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