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前胡丙素对豚鼠心房和兔主动脉条的钙拮抗作用
引用本文:吴欣 饶曼人. 前胡丙素对豚鼠心房和兔主动脉条的钙拮抗作用[J]. 中国药理学与毒理学杂志, 1990, 4(2): 104-106
作者姓名:吴欣 饶曼人
作者单位:南京医学院心血管药理研究室,南京医学院心血管药理研究室 南京 210005 南京中医学院中药研究室,210005,南京 210005
摘    要:
前胡丙素(Pra—C)非竞争性抑制CaCl_2和高钾除极化所致兔主动脉条的收缩,pD’_2值分别为4.9和5.0;抑制5—HT诱导的依外钙性收缩,但不影响依内钙性收缩及NE诱导的收缩;Pra—C5~50μmol/L浓度依赖性地抑制豚鼠左房收缩力和阶梯现象;Pra—C抑制血管与心脏的IC_(50)之比为1:8。结果提示Pra—C对血管和心脏的抑制作用可能与拮抗Ca~(2+)有关,且主要影响经PDCs的外钙内流。

关 键 词:前胡丙素  兔主动脉条  豚鼠心房  收缩性  细胞内外钙

Calcium-antagonistic effects of praeruptorin C on isolated guinea pig atria and rabbit aorta
WUXin,RAO Man-Ren. Calcium-antagonistic effects of praeruptorin C on isolated guinea pig atria and rabbit aorta[J]. Chinese Journal of Pharmacology and Toxicology, 1990, 4(2): 104-106
Authors:WUXin  RAO Man-Ren
Abstract:
In the isolated rabbit aorta,praerup-torin C(Pra-C)inhibited the contractions induced by calcium and potassium depolarization and shifted the concentration-response curve nonparallelly to right.pD2 value is 4.9 and 5.0 respectively.It did not possess relevant antagonistic effects against norepinephrine-induced contractions and significantly inhibited the sustained tonic but not the initial phasic component of the contractions induced by serotonin,showing itslittle effect on the intracellular calcium release.At the concentration of 5-50μmol/L,Pra-C inhibited the contractility and staircase phenomenon of the left atria in a dose-dependant manner but seldom affected post-rest potentiation.These results indicated that Pra-C had calcium-antagonistic effects on the isolated rabbit aorta and guinea pig atria and mainly blocked calcium influx through PDCs.
Keywords:praeruptorin C  rabbit aorta  guinea pig atria  contractility  intra- and extracellular calcium
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