Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study |
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| Authors: | Ya Wang Ke Li Ya‐Wei Zeng Simon S. Y. Lui Eric F. C. Cheung Zhen Jin Paola Dazzan David C. Glahn Raymond C. K. Chan |
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| Affiliation: | 1. Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;2. Department of Psychology, The University of Chinese Academy of Sciences, Beijing, China;3. MRI Center, Hospital 306, Beijing, China;4. Castle Peak Hospital, Hong Kong Special Administrative Region, Hong Kong, China;5. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom;6. National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, London, United Kingdom;7. Department of Psychiatry, Yale University & Olin Neuropsychiatric Research Center, Institute of Living, United States of America |
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| Abstract: | ![]()
Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist‐edge‐palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty‐six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre‐ and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable. |
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| Keywords: | audiovisual integration fist‐edge‐palm fMRI healthy twin heritability |
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