A roadmap to advance dementia research in prevention,diagnosis, intervention,and care by 2025 |
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| Authors: | James Pickett Cathy Bird Clive Ballard Sube Banerjee Carol Brayne Katherine Cowan Linda Clare Adelina Comas‐Herrera Lynne Corner Stephanie Daley Martin Knapp Louise Lafortune Gill Livingston Jill Manthorpe Natalie Marchant Jo Moriarty Louise Robinson Clare van Lynden Gill Windle Bob Woods Katherine Gray Clare Walton |
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| Institution: | 1. Alzheimer's Society, London, UK;2. Alzheimer's Society Research Network Volunteer, Alzheimer's Society, London, UK;3. University of Exeter Medical School, University of Exeter, Exeter, UK;4. Centre for Dementia Studies, Brighton and Sussex Medical School, University of Sussex, Sussex, UK;5. Cambridge Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, UK;6. Katherine Cowan Consulting Ltd, East Sussex, UK;7. Centre for Research in Ageing and Cognitive Health, University of Exeter, Exeter, UK;8. PSSRU, London School of Economics and Political Science, London, UK;9. Institute for Ageing, Newcastle University, Newcastle upon Tyne, UK;10. Institute for Health & Society, Newcastle University, Newcastle upon Tyne, UK;11. Division of Psychiatry, University College London, London, UK;12. Social Care Workforce Research Unit, King's College London, London, UK;13. Alzheimer's Research UK, Great Abington, UK;14. Dementia Services Development Centre, Bangor University, Bangor, Gwynedd, Wales, UK |
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| Abstract: | Objective National and global dementia plans have focused on the research ambition to develop a cure or disease‐modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. Methods Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research. Results The taskforce developed 5 goals and 30 recommendations. The goals focused on preventing future cases of dementia through risk reduction, maximising the benefit of a dementia diagnosis, improving quality of life, enabling the dementia workforce to improve practice, and optimising the quality and inclusivity of health and social care systems. Recommendations addressed gaps in knowledge and limitations in research methodology or infrastructure that would facilitate research in prioritised areas. A 10‐point action plan provides strategies for delivering the proposed research agenda. Conclusions By creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives. This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families. |
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| Keywords: | care dementia research policy prevention research funding risk reduction social and applied science 2025 goals for dementia |
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