Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease |
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| Authors: | Salah Amasheh Sonja Dullat Michael Fromm Jörg D. Schulzke Heinz J. Buhr Anton J. Kroesen |
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| Affiliation: | 1.Institute of Clinical Physiology,CBF, Charité, Freie Universit?t und Humboldt Universit?t,Berlin,Germany;2.Department of Surgery,CBF, Charité, Freie Universit?t und Humboldt Universit?t,Berlin,Germany;3.Department of General Medicine,CBF, Charité, Freie Universit?t und Humboldt Universit?t,Berlin,Germany;4.Department of Gastroenterology, Infectious Diseases, and Rheumatology,CBF, Charité, Freie Universit?t und Humboldt Universit?t,Berlin,Germany |
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| Abstract: | ![]()
Background and aims The etiology of pouchitis after coloproctomucosectomy with ileal pouch-anal anastomosis in patients with ulcerative colitis is still unknown. Beside changes in luminal antigens, the immunological predisposition is assumed to be responsible. In previous electrophysiological studies, we showed that mucosal barrier and transport function in pouchitis is markedly reduced. Thus, the aim of the present study was to analyze barrier function on the molecular level. |
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