Effect of PAF on erythrocyte membrane heterogeneity: A fluorescence study |
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| Authors: | A. Kantar P. L. Giorgi G. Curatola R. Fiorini |
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| Affiliation: | (1) Department of Pediatrics, University of Ancona, via corridoni 11, 60123 Ancona, Italy;(2) Department of Biochemistry, University of Ancona, via corridoni 11, 60123 Ancona, Italy |
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| Abstract: | ![]()
The effect of platelet activating factor, PAF, on the erythrocyte membrane heterogeneity was investigated by measuring the steady-state fluorescence anisotropy and fluorescence decay of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated in hemoglobin-free erythrocyte membranes. PAF induced a significant increase of the lipid order in the exterior part of the membrane and a decrease in membrane heterogeneity. These results indicate that PAF may cause changes in the physico-chemical structure of the erythrocyte membrane. |
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