可分剂量甲磺酸二氢麦角碱缓释微囊片的制备及体外释放机制的研究

目的对可分剂量甲磺酸二氢麦角碱缓释微囊片(EDDTEM)的处方进行研究,并研究其体外释放机制。方法以海藻酸钠-壳聚糖为囊材,采用复凝聚法制备甲磺酸二氢麦角碱缓释微囊(EEM)并压制成片,采用正交设计实验优化处方。结果EEM的最优处方为:海藻酸钠与药物比例为6∶1,海藻酸钠-壳聚糖比例为4∶1,海藻酸钠浓度为2.5%。所制缓释片释药行为符合Higuchi方程,释药机理为扩散和溶蚀并存。结论EDDTEM具有良好的体外缓释效果,可进一步进行体内释药行为考察。

Studies on Preparation and Dissolution Mechanism in Vitro of Ergoloid Mesylates Divided Dose Tablet of Extended-Release Microcapsule

OBJECTIVE To review the advances on pharmacokinetic-pharmacodynamic (PK-PD) modeling. METHODS On the basis of analysing and concluding the relevant articles for the last ten years, the types, programs and application of PK-PD modeling were summarized. RESULTS There are four kinds of pharmacokinetic-pharmacodynamic (PK-PD) modeling, which were widely applied on drug development, individual administration and clinical detection, providing useful information to guide clinical medication. CONCLUSION PK-PD modeling has been improved and plays important role in drug development with its deep study.