Exacerbation of Partial Seizures and Onset of Nonepileptic Myoclonus with Carbamazepine |
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Authors: | Anil Dhuna Alvaro Pascual-Leone Dinesh Talwar |
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Institution: | Department of Neurology, University of Minnesota, Minneapolis 55455. |
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Abstract: | A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal EEG by focal right temporal lobe discharges. The seizure exacerbation, which was associated with development of nonepileptic, multifocal myoclonus, resolved 24 h after CBZ was discontinued. The exacerbation occurred with therapeutic CBZ serum levels, but may have been related to the toxic levels of carbamazepine-10, 11-epoxide (CBZE). |
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Keywords: | Carbamazepine Partial complex seizures Exacerbation Multifocal nonepileptic myoclonus |
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