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Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease |
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| Authors: | P. P. Liberski R. Yanagihara C. J. Gibbs Jr. D. C. Gajdusek |
| Affiliation: | (1) Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 36, Rm. 5B-21, 20892 Bethesda, MD, USA;(2) Present address: Department of Oncology, Medical Academy Lodz, Electron Microscopic Laboratory, Lodz, Poland |
| Abstract: | Summary We report the presence of autophagic vacuoles (AV) in neuronal perikarya and neuronal processes of rodents with experimental scrapie and Creutzfeldt-Jakob disease. AV were composed of sequestrated cytoplasmic areas containing ribosomes and occasionally mitochondria and small secondary vacuoles. The formation of AV may contribute to neuronal degeneration and ultimately to neuronal loss.P. P. Liberski is a recipient of a fellowship from the Fogarty International Center and a grant from the Polish Academy of Sciences (VIII/40) |
| Keywords: | Scrapie Creutzfeldt-Jakob disease Neuronal autophagy Neuropathology Electron microscopy |
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