心肌康对左心室肥厚逆转作用的临床研究

本研究应用中药心肌康对左心室肥厚（ＬＶＨ）患者进行逆转性治疗。９４例ＬＶＨ患者随机分为心肌康治疗组（７４例）和美多心安对照组（２０例），作服药前后的临床疗效观察。结果表明：心肌康对ＬＶＨ有显著的退缩作用（Ｐ＜０．０５，Ｐ＜０．０１），对照组对ＬＶＨ的治疗虽有一定程度的改善，但无统计学意义，两组于治疗后比较亦呈显著性差异（Ｐ＜０．０１）。心肌康对ＬＶＨ的病因具有缓解或消除的作用，如心功能和微循环的改善，血粘度、血载脂蛋白Ａ－１（ＡＰＯＡ－１）、心肌耗氧量（ＲＰＰ）的降低和超氧化物歧化酶（ＳＯＤ）升高等，治疗前后均有显著性差异，与对照组比较，亦具有统计学意义（Ｐ＜０．０５或Ｐ＜０．０１）。上述结果提示心肌康对ＬＶＨ具有一定的逆转作用。

Clinical Study on Effect of Xinjikang Capsule in Reversing Left Ventricular Hypertrophy

The study was conducted on the patients suffering from left ventricular hypertrophy (LVH).Ninety four cases of LVH were randomly divided into treated group (74 cases) and control group (20 cases) treated with Xinjikang capsule (XJK) and Metoprolo respectively. The results showed that XJK has remarkable reverse effects on LVH (P<0.01).The control group although showed some effect of improvement, in comparison with pretreatmental measurement the difference was insignificanty (P>0.05).While in comparing the two groups, the difference of effect was very significant (P<0.01). XJK could also alleviate and eliminate to the cause of LVH, such as improving heart function and microcirculation, decreasing blood viscosity, apolipoprotein, myocardial oxygen consumption, increasing superoxide dismutase. All these parameters measured after XJK treatment were significantly different from that before treatment. The difference of them between XJK treated group and control group was also significant (P<0. 01 or P<0. 05).It suggested XJK capsule has reversing effect on LVH.