小儿肝硬化38例临床分析

目的：探讨小儿肝硬化的病因和临床特征。方法：对38例小儿肝硬化进行病因、临床特征及治疗和转归的分析，并与同时期成人肝硬化对比。结果：小儿肝硬化23例(60．5％)，其中乙型肝炎19例；其次胆汁性肝硬化4例(10．5％)、前瞻性静脉海绵样变性3例(7．9％)。小儿肝硬化主要症状为乏力、纳差、浮肿，体征以肝脾肿大、腹水、黄疸多见，肝掌、蜘蛛痣少见。结论：实验室检查对小儿肝硬化无特异性诊断价值。小儿肝硬化的预后除与病因有关外，还取决于早期诊断和及时治疗。

Clinical Analysis of 38 Children with Hepatic Cirrhosis

Objective To study etiology and clinical features of hepatic cirrhosis in children. Methods The etiology, clinical features, therapy and prognosis of 38 cases of children hepatic cirrhosis were studied and compared with hepatic cirrhosis in adult of the same stage. Results 23 cases with liver cirrhosis (60.5% of total) in which19 patients with hepatitis B virus. 4 cases (10.5%) with biliary hepatitc cirrhosis, 3 cases(7.9%) with portal spongy degeneration, and 3 cases(7.9%) with hepatolenticular degeneration (wilson's desease). The main symptoms of hepatic cirrhosis in children were fatigue, anorexia, edema, hepatosplenomegaly, ascites and icterus. Liver palms and spider nevus were rare. Conclusions Laboratory examination is of no value for specific diagnosis of hepatic cirrhosis in children. Prognosis of hepatic cirrhosis in children depends on early diagnosis and early therapy other than etiology.