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Deriving pediatric nerve conduction normal values in the very young (<3 years)
Affiliation:1. Department of Paediatrics, Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;2. Department of Pediatrics, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia;1. Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey;2. Department of Pediatric Neurology, Sami Ulus Children''s Hospital, Ankara, Turkey;3. Department of Neurology, Hacettepe University, Ankara, Turkey;1. Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, UK;2. Division of Pediatric Neurology, University Children''s Hospital Basel (UKBB), University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland;3. Division of Neurology, Medical University Clinic, Kantonsspital Baselland, Switzerland;4. Division of Neuropathology, UCL Institute of Neurology, London, UK;5. Dubowitz Neuromuscular Centre, MRC Centre for Neuromuscular Diseases, UCL Great Ormond Street Institute of Child Health, London, UK;6. Department of Pediatric Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, UK;7. Department of Clinical Neurophysiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK;8. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;9. Wolfson Centre for Inherited Neuromuscular Diseases, The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK;10. National Institute for Health Research, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK
Abstract:
ObjectiveThis work describes our efforts to obtain nerve conduction studies normal values in a pediatric cohort between birth and 3 years of age using the extrapolated norms or e-norms method. Interpretation of these studies poses major challenges when no reliable normal values can be found in the literature.MethodsThe e-norms method was used to derive a reference range of upper and lower extremity sensory and motor nerve conductions normal values from a pediatric cohort referred to an EMG Laboratory for nerve conduction studies.ResultsE-norms were calculated for Median, Ulnar, Superficial Peroneal, Sural, and Medial Plantar sensory studies, and for Median, Ulnar, Peroneal, and Tibial motor studies.ConclusionsPediatric electrodiagnostic testing is a very challenging undertaking. The ability to obtain and use normal values from the neurophysiologist’s own referral pool adds great value to their diagnostic work-up.SignificanceEMG and nerve conduction studies can yield invaluable information in the diagnostic work-up of young infants. Using the e-norms method improves on the analysis and interpretation of electrophysiological studies in this age group.
Keywords:Pediatric normal values  Sensory  Motor  Nerve conductions  E-norms  E-norms"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Extrapolated norms  EMG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Electromyography  IRB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Institutional Review Board  S"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Sensory  M"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Motor  Lat"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Latency  CV"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Conduction Velocity  P-W"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Palm-Wrist  Sup Per"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Superficial Peroneal  Med Plant"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Medial Plantar  APB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Abductor Pollicis Brevis  ADM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Abductor Digiti Minimi  EDB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Extensor Digitorum Brevis  AH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  k0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Abductor Hallucis
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