Deriving pediatric nerve conduction normal values in the very young (<3 years) |
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Affiliation: | 1. Department of Paediatrics, Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;2. Department of Pediatrics, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia;1. Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey;2. Department of Pediatric Neurology, Sami Ulus Children''s Hospital, Ankara, Turkey;3. Department of Neurology, Hacettepe University, Ankara, Turkey;1. Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, UK;2. Division of Pediatric Neurology, University Children''s Hospital Basel (UKBB), University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland;3. Division of Neurology, Medical University Clinic, Kantonsspital Baselland, Switzerland;4. Division of Neuropathology, UCL Institute of Neurology, London, UK;5. Dubowitz Neuromuscular Centre, MRC Centre for Neuromuscular Diseases, UCL Great Ormond Street Institute of Child Health, London, UK;6. Department of Pediatric Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, UK;7. Department of Clinical Neurophysiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK;8. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada;9. Wolfson Centre for Inherited Neuromuscular Diseases, The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK;10. National Institute for Health Research, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK |
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Abstract: | ObjectiveThis work describes our efforts to obtain nerve conduction studies normal values in a pediatric cohort between birth and 3 years of age using the extrapolated norms or e-norms method. Interpretation of these studies poses major challenges when no reliable normal values can be found in the literature.MethodsThe e-norms method was used to derive a reference range of upper and lower extremity sensory and motor nerve conductions normal values from a pediatric cohort referred to an EMG Laboratory for nerve conduction studies.ResultsE-norms were calculated for Median, Ulnar, Superficial Peroneal, Sural, and Medial Plantar sensory studies, and for Median, Ulnar, Peroneal, and Tibial motor studies.ConclusionsPediatric electrodiagnostic testing is a very challenging undertaking. The ability to obtain and use normal values from the neurophysiologist’s own referral pool adds great value to their diagnostic work-up.SignificanceEMG and nerve conduction studies can yield invaluable information in the diagnostic work-up of young infants. Using the e-norms method improves on the analysis and interpretation of electrophysiological studies in this age group. |
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Keywords: | Pediatric normal values Sensory Motor Nerve conductions E-norms E-norms" },{" #name" :" keyword" ," $" :{" id" :" k0035" }," $$" :[{" #name" :" text" ," _" :" Extrapolated norms EMG" },{" #name" :" keyword" ," $" :{" id" :" k0045" }," $$" :[{" #name" :" text" ," _" :" Electromyography IRB" },{" #name" :" keyword" ," $" :{" id" :" k0055" }," $$" :[{" #name" :" text" ," _" :" Institutional Review Board S" },{" #name" :" keyword" ," $" :{" id" :" k0065" }," $$" :[{" #name" :" text" ," _" :" Sensory M" },{" #name" :" keyword" ," $" :{" id" :" k0075" }," $$" :[{" #name" :" text" ," _" :" Motor Lat" },{" #name" :" keyword" ," $" :{" id" :" k0085" }," $$" :[{" #name" :" text" ," _" :" Latency CV" },{" #name" :" keyword" ," $" :{" id" :" k0095" }," $$" :[{" #name" :" text" ," _" :" Conduction Velocity P-W" },{" #name" :" keyword" ," $" :{" id" :" k0105" }," $$" :[{" #name" :" text" ," _" :" Palm-Wrist Sup Per" },{" #name" :" keyword" ," $" :{" id" :" k0115" }," $$" :[{" #name" :" text" ," _" :" Superficial Peroneal Med Plant" },{" #name" :" keyword" ," $" :{" id" :" k0125" }," $$" :[{" #name" :" text" ," _" :" Medial Plantar APB" },{" #name" :" keyword" ," $" :{" id" :" k0135" }," $$" :[{" #name" :" text" ," _" :" Abductor Pollicis Brevis ADM" },{" #name" :" keyword" ," $" :{" id" :" k0145" }," $$" :[{" #name" :" text" ," _" :" Abductor Digiti Minimi EDB" },{" #name" :" keyword" ," $" :{" id" :" k0155" }," $$" :[{" #name" :" text" ," _" :" Extensor Digitorum Brevis AH" },{" #name" :" keyword" ," $" :{" id" :" k0165" }," $$" :[{" #name" :" text" ," _" :" Abductor Hallucis |
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