Practice-dependent motor cortex plasticity is reduced in non-disabled multiple sclerosis patients |
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Affiliation: | 1. Unit of Neurology and Neurorehabilitation, IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, IS, Italy;2. Laboratory of Synaptic Immunopathology, Department of Systems Medicine, Tor Vergata University, Via Montpellier 1, 00133 Rome, Italy;3. Service of Medical Statistics & Information Technology, Fondazione Fatebenefratelli per la Ricerca e la Formazione Sanitaria e Sociale, Lungotevere de'' Cenci 5, 00186 Rome, Italy;1. Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Germany;2. Sagol Brain Institute, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center and School of Psychological Sciences, Tel-Aviv University, Israel;3. Department Neuroimaging, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Germany;4. Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada |
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Abstract: | ObjectivesSkill acquisition after motor training involves synaptic long-term potentiation (LTP) in primary motor cortex (M1). In multiple sclerosis (MS), LTP failure ensuing from neuroinflammation could contribute to worsen clinical recovery. We therefore addressed whether practice-dependent plasticity is altered in MS.MethodsEighteen relapsing-remitting (RR)-MS patients and eighteen healthy controls performed 600 fast abductions of index finger in 30 blocks of 20 movements. Before and after practice, transcranial magnetic stimulation (TMS) was delivered over the hot spot of the trained first dorsal interosseous muscle. Movements kinematics, measures of cortical excitability, and the input/output curves of motor evoked potentials (MEPs) were assessed.ResultsKinematic variables of movement improved with practice in patients and controls to a similar extent, although patients showed lower MEPs amplitude increase after practice. Practice did not change the difference in resting motor threshold values observed between patients and controls, nor did modulate short-interval intracortical inhibition. Clinical/radiological characteristics were not associated to practice-dependent effects.ConclusionsPractice-induced reorganization of M1 is altered in non-disabled RR-MS patients, as shown by impaired MEPs modulation after motor learning.SignificanceThese findings suggest that in RR-MS physiological mechanisms of practice-dependent plasticity are altered. |
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Keywords: | Early motor learning Multiple sclerosis (MS) Synaptic plasticity Long-term potentiation (LTP) Transcranial magnetic stimulation (TMS) Neuroinflammation ACC" },{" #name" :" keyword" ," $" :{" id" :" k0040" }," $$" :[{" #name" :" text" ," _" :" peak acceleration AMT" },{" #name" :" keyword" ," $" :{" id" :" k0050" }," $$" :[{" #name" :" text" ," _" :" active motor threshold CS" },{" #name" :" keyword" ," $" :{" id" :" k0060" }," $$" :[{" #name" :" text" ," _" :" conditioning stimulus cMAPs" },{" #name" :" keyword" ," $" :{" id" :" k006033" }," $$" :[{" #name" :" text" ," _" :" compound muscle action potentials EDSS" },{" #name" :" keyword" ," $" :{" id" :" k0070" }," $$" :[{" #name" :" text" ," _" :" expanded disability status scale FDI" },{" #name" :" keyword" ," $" :{" id" :" k0080" }," $$" :[{" #name" :" text" ," _" :" first dorsal interosseous fMRI" },{" #name" :" keyword" ," $" :{" id" :" k0090" }," $$" :[{" #name" :" text" ," _" :" functional MRI FSS" },{" #name" :" keyword" ," $" :{" id" :" k0100" }," $$" :[{" #name" :" text" ," _" :" fatigue severity scale I/O" },{" #name" :" keyword" ," $" :{" id" :" k0110" }," $$" :[{" #name" :" text" ," _" :" input/output ICF" },{" #name" :" keyword" ," $" :{" id" :" k0120" }," $$" :[{" #name" :" text" ," _" :" intracortical facilitation ISI" },{" #name" :" keyword" ," $" :{" id" :" k0130" }," $$" :[{" #name" :" text" ," _" :" interstimulus interval LTP" },{" #name" :" keyword" ," $" :{" id" :" k0140" }," $$" :[{" #name" :" text" ," _" :" long-term potentiation LST" },{" #name" :" keyword" ," $" :{" id" :" k0140222" }," $$" :[{" #name" :" text" ," _" :" lesion segmentation toolbox M1" },{" #name" :" keyword" ," $" :{" id" :" k0150" }," $$" :[{" #name" :" text" ," _" :" primary motor cortex MEP" },{" #name" :" keyword" ," $" :{" id" :" k0160" }," $$" :[{" #name" :" text" ," _" :" motor evoked potentials MRI" },{" #name" :" keyword" ," $" :{" id" :" k016022" }," $$" :[{" #name" :" text" ," _" :" magnetic resonance imaging MS" },{" #name" :" keyword" ," $" :{" id" :" k0170" }," $$" :[{" #name" :" text" ," _" :" multiple sclerosis RMT" },{" #name" :" keyword" ," $" :{" id" :" k0180" }," $$" :[{" #name" :" text" ," _" :" resting motor threshold RR" },{" #name" :" keyword" ," $" :{" id" :" k0190" }," $$" :[{" #name" :" text" ," _" :" relapsing-remitting SICI" },{" #name" :" keyword" ," $" :{" id" :" k0200" }," $$" :[{" #name" :" text" ," _" :" short-interval intracortical inhibition SMA" },{" #name" :" keyword" ," $" :{" id" :" k0200221" }," $$" :[{" #name" :" text" ," _" :" supplementary motor area TMS" },{" #name" :" keyword" ," $" :{" id" :" k0210" }," $$" :[{" #name" :" text" ," _" :" transcranial magnetic stimulation TS" },{" #name" :" keyword" ," $" :{" id" :" k0220" }," $$" :[{" #name" :" text" ," _" :" test stimulus T2Ln" },{" #name" :" keyword" ," $" :{" id" :" k0220566" }," $$" :[{" #name" :" text" ," _" :" total number of lesions T2Lv" },{" #name" :" keyword" ," $" :{" id" :" k0220344" }," $$" :[{" #name" :" text" ," _" :" total lesion volume VEL" },{" #name" :" keyword" ," $" :{" id" :" k0230" }," $$" :[{" #name" :" text" ," _" :" peak velocity |
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