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CYP2D6 and GSTM1 genotypes in a Polish population |
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| Authors: | B. Gawronska-Szklarz M. Wójcicki A. Kuprianowicz K. Kedzierska M. Kedzierski W. Górnik A. Pawlik |
| Affiliation: | (1) Department of Pharmacology and Toxicology, Laboratory of Pharmacokinetics and Monitoring Therapy, Medical University, Powstanców Wlkp. 72, PL-70-111 Szczecin, Poland e-mail: gszklarz@r1.pam.szczecin.pl Tel.: +48-91-4820863; Fax: +48-91-4828539, PL;(2) Department of General and Transplantation Surgery, Medical University, Powstanców Wlkp. 72, 70-111 Szczecin, Poland, PL |
| Abstract: | Objective: The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population. Methods: One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6 * 3 and CYP2D6 * 4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative). Results: Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6 * 4 and CYP2D6 * 3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%. Conclusion: The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations. Received: 29 October 1998 / Accepted in revised form: 15 March 1999 |
| Keywords: | Genetic polymorphism CYP2D6 GSTM1 |
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