|
|||||
|
|
| 乙型肝炎免疫球蛋白阻断HBV宫内感染的效果观察 | |
| 引用本文： | 王军,卢永欣,邱德山. 乙型肝炎免疫球蛋白阻断HBV宫内感染的效果观察[J]. 医学动物防制, 2011, 0(5): 422-423 |
| 作者姓名： | 王军 卢永欣 邱德山 |
| 作者单位： | 潍坊市坊子区人民医院;潍坊市疾病预防控制中心; |
| 摘 要： | 目的了解孕期乙肝免疫球蛋白(HBIG)阻断乙肝病毒宫内感染的疗效。方法选择2009-2010年在我院产科门诊定期产前检查并住院分娩的HBsAg阳性孕妇360例,观察组196例,于孕28、32、36周肌注HBIG 200IU,对照组164例不用药。用酶联免疫吸附试验(ELISA)和荧光定量PCR检测2组新生儿采股静脉血,检测乙肝病毒标志物和HBV-DNA。结果 HBIG对HBsAg单阳性和合并抗-HBe、抗-HBc阳性率分别为6.35%、22.81%和12.50%、32.20%,2组差异有统计学意义(P<0.05)。合并HBeAg、抗-HBc的阳性率为7.25%和16.67%,2组差异无统计学意义(P>0.05)。结论孕妇于孕晚期多次肌注HBIG进行被动免疫,可阻断HBV宫内感染,但HbeAg阳性产妇阻断无明显效果。 |
| 关 键 词： | 乙肝免疫球蛋白 乙肝病毒 宫内感染 |
Observation the effect of hepatitis B immune globulin blocks HBV intrauterine infection |
|
| WANG Jun,LU Yong-xin,QIU De-shan.Fangzi District People Hospital,Sh,ong ,China.. Observation the effect of hepatitis B immune globulin blocks HBV intrauterine infection[J]. Chinese Journal of Pest Control, 2011, 0(5): 422-423 | |
| Authors: | WANG Jun LU Yong-xin QIU De-shan.Fangzi District People Hospital Sh ong China. |
| Affiliation: | WANG Jun,LU Yong-xin,QIU De-shan.Fangzi District People Hospital,Shandong 261200,China. |
| Abstract: | Objective To understand the curative effect of hepatitis B immune globulin(HBIG) block HBV intrauterine infection.Method Choosing 360 HBsAg positive pregnant women with regular antenatal care and giving birth in our hospital,196 patients were intramuscular HBIG 200U at the pregnant time of 28,32,36 week.In control group,164 samples did not given drugs.Collecting femoral vein blood of newborns and detecting HBVM and HBV-DNA in blood by ELISA and Real-time Quantitative PCR.Results In two group,the positive ra... |
| Keywords: | Hepatitis B immune globulin Hepatitis B virus Intrauterine infection |
| 本文献已被 CNKI 维普 等数据库收录！ | |