| 糖尿病动物模型P物质含量的变化及其意义 |
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| 引用本文： | 计敏,林琳,赵志泉. 糖尿病动物模型P物质含量的变化及其意义[J]. 南京医科大学学报(自然科学版), 2002, 22(4): 291-292,298 |
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| 作者姓名： | 计敏 林琳 赵志泉 |
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| 作者单位： | 南京医科大学第一附属医院消化科,江苏南京,210029;南京医科大学第一附属医院消化科,江苏南京,210029;南京医科大学第一附属医院消化科,江苏南京,210029 |
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| 基金项目： | 江苏省科委社会发展基金资助项目(123BD9902) |
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| 摘 要： | 目的：研究P物质在糖尿病大鼠血浆和肠道组织中的变化及意义。方法：用放射免疫法分别检测糖尿病大鼠（10只）和正常大鼠（10只）血浆和十二指肠、远端结肠组织中P物质的含量。结果：糖尿病大鼠血浆P物质含量明显低于正常对照组（P＜0．05）。十二指肠、远端结肠中含量明显高于正常对照组（P＜0．05）。结论：肠道组织中P物质的变化在糖尿病胃肠功能障碍中起一定作用。
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| 关 键 词： | 糖尿病 P物质 大鼠 |
| 文章编号： | 1007-4368(2002)04-0291-03 |
Substance P of Plasma and Enteric Tissues in Diabetic Rats |
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| JI Min,LIN Lin,ZHAO Zhi quan. Substance P of Plasma and Enteric Tissues in Diabetic Rats[J]. Acta Universitatis Medicinalis Nanjing, 2002, 22(4): 291-292,298 |
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| Authors: | JI Min LIN Lin ZHAO Zhi quan |
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| Abstract: | Objective:To investigate the change and significance of Substance P (SP)in diabetic rats.Methods:The SP in plasma, duodenum and distal colon were measured by the radioimmunoassay (RIA) in normal rats (n=10) and the diabetic rats (n=10)respectively.Results:The plasma SP in diabetic rats was significantly lower than those in normal group (P< 0.05). In the duodenum and distal colon of diabetic rats SP levels were higher than those of the controls(P< 0.05).Conclusion:The abnormalities observed in animal model for diabetes might have relevance for the gastrointestinal dysmotility displayed in human diabetes. |
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| Keywords: | diabetic substance P rats |
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