| 冠心病家族史大学生apo E基因多态性的临床研究 |
| |
| 引用本文： | 李洁,张天民,李莎,詹如冰,林清霞,黎明. 冠心病家族史大学生apo E基因多态性的临床研究[J]. 国外医学:心血管疾病分册, 2003, 30(4): 248-250 |
| |
| 作者姓名： | 李洁 张天民 李莎 詹如冰 林清霞 黎明 |
| |
| 作者单位： | 广东工业大学医院心内科 510090(李洁，林清霞)，武汉科技大学医学院 430080(张天民)，广州市东山人民医院 510080(李莎)，广东省人民医院 510080(詹如冰)，广东工业大学医院心内科 510090(黎明) |
| |
| 基金项目： | 广东工业大学立项资助课题,项目编号:202002 |
| |
| 摘 要： | 目的:探讨大学生载脂蛋白E(apoE)基因多态性,及其对血脂代谢紊乱、动脉粥样硬化(AS)和冠心病(CHD)的影响。方法:对广东地区高校152名健康汉族大学生,在问卷调查的基础上,根据一、二级亲属有无CHD病史分为阳性组与对照组,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行apoE基因分析。结果:有CHD家族史的阳性组e_4等位基因频率显著高于无CHD家族史的阴性组(P<0.05)。结论:apoE基因多态性与AS、CHD易感性密切有关,e_4可能是CHD的重要遗传因子。
|
| 关 键 词： | 冠心病 家族史 载脂蛋白E 基因多态性 动脉粥样硬化 血脂代谢紊乱 聚合酶链反应-限制性片段长度多态性 |
Relationship between apolipoprotein E gene polymorphism and atherosclerosis and coronary heart disease in college students |
| |
| LI Jie,ZHANG Tianmin,LI Sha,et al.. Relationship between apolipoprotein E gene polymorphism and atherosclerosis and coronary heart disease in college students[J]. , 2003, 30(4): 248-250 |
| |
| Authors: | LI Jie ZHANG Tianmin LI Sha et al. |
| |
| Affiliation: | LI Jie,ZHANG Tianmin,LI Sha,etal. Dept. of Cardiology,Hospital of Guangdong U-niversity of Technology,Guangdong 510090 |
| |
| Abstract: | Objective: To investigate the effect of apolipoprotein E(apo E) gene polymorphism on blood lipids metabolism and the incidence of atherosclerosis (AS) and coronary heart disease (CHD) in college students . Methods: One hundred fifty two healthy students of Han nationality in the universities of Guangdong region were investigated by using polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) analysis. With the help of information from questionnaire, they were divded into 2 groups according to whether or not they had positive CHD family history and then they underwent apoE genotype analysis. Results: The allele frequency of apo e4 in positive group was significantly higher than that of negative group (P<0.05). Conclusions: The apo E gene polymorphism correlated significantly with susceptibility to AS and CHD, and e4 may be an important genetic factor of CHD. |
| |
| Keywords: | Apolipoprotein E Gene Polymorphism CHD |
| 本文献已被 CNKI 等数据库收录！ |
|
