| 冠心病家族史大学生apo E基因多态性的临床研究 |
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| 引用本文： | 李洁,张天民,李莎,詹如冰,林清霞,黎明.冠心病家族史大学生apo E基因多态性的临床研究[J].国外医学：心血管疾病分册,2003,30(4):248-250. |
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| 作者姓名： | 李洁 张天民 李莎 詹如冰 林清霞 黎明 |
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| 作者单位： | 广东工业大学医院心内科 510090
(李洁，林清霞)，武汉科技大学医学院 430080
(张天民)，广州市东山人民医院 510080
(李莎)，广东省人民医院 510080
(詹如冰)，广东工业大学医院心内科 510090(黎明) |
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| 基金项目： | 广东工业大学立项资助课题,项目编号:202002 |
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| 摘 要： | 目的:探讨大学生载脂蛋白E(apoE)基因多态性,及其对血脂代谢紊乱、动脉粥样硬化(AS)和冠心病(CHD)的影响。方法:对广东地区高校152名健康汉族大学生,在问卷调查的基础上,根据一、二级亲属有无CHD病史分为阳性组与对照组,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法进行apoE基因分析。结果:有CHD家族史的阳性组e_4等位基因频率显著高于无CHD家族史的阴性组(P<0.05)。结论:apoE基因多态性与AS、CHD易感性密切有关,e_4可能是CHD的重要遗传因子。
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| 关 键 词： | 冠心病 家族史 载脂蛋白E 基因多态性 动脉粥样硬化 血脂代谢紊乱 聚合酶链反应-限制性片段长度多态性 |
Relationship between apolipoprotein E gene polymorphism and atherosclerosis and coronary heart disease in college students |
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| Authors: | LI Jie ZHANG Tianmin LI Sha |
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| Institution: | LI Jie,ZHANG Tianmin,LI Sha,etal. Dept. of Cardiology,Hospital of Guangdong U-niversity of Technology,Guangdong 510090 |
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| Abstract: | Objective: To investigate the effect of apolipoprotein E(apo E) gene polymorphism on blood lipids metabolism and the incidence of atherosclerosis (AS) and coronary heart disease (CHD) in college students . Methods: One hundred fifty two healthy students of Han nationality in the universities of Guangdong region were investigated by using polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) analysis. With the help of information from questionnaire, they were divded into 2 groups according to whether or not they had positive CHD family history and then they underwent apoE genotype analysis. Results: The allele frequency of apo e4 in positive group was significantly higher than that of negative group (P<0.05). Conclusions: The apo E gene polymorphism correlated significantly with susceptibility to AS and CHD, and e4 may be an important genetic factor of CHD. |
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| Keywords: | Apolipoprotein E Gene Polymorphism CHD |
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