| HPLC法测定威喜丸中猪苓酮B、猪苓酮A、去氢土莫酸、猪苓酸C、去氢茯苓酸和茯苓酸 |
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| 引用本文： | 赵丹,魏谭军,晏明英,唐启荣,何人大,岳剑东,刘岩庭.HPLC法测定威喜丸中猪苓酮B、猪苓酮A、去氢土莫酸、猪苓酸C、去氢茯苓酸和茯苓酸[J].现代药物与临床,2019,34(1):27-30. |
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| 作者姓名： | 赵丹 魏谭军 晏明英 唐启荣 何人大 岳剑东 刘岩庭 |
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| 作者单位： | 达州市中西医结合医院,四川达州,635000;福建省食品药品质量检验研究院,福建福州,350001 |
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| 摘 要： | 目的建立HPLC波长切换法同时测定威喜丸中猪苓酮B、猪苓酮A、去氢土莫酸、猪苓酸C、去氢茯苓酸和茯苓酸的方法。方法采用Agilent Eclipse XDB-C18色谱柱(250 mm×4.6 mm,5μm);流动相:乙腈–0.05%磷酸溶液,梯度洗脱;0～24.0 min在248 nm波长下检测猪苓酮B和猪苓酮A,24.0～50.0 min在210 nm波长下检测去氢土莫酸、猪苓酸C、去氢茯苓酸和茯苓酸;体积流量1.0m L/min;柱温30℃;进样量为10μL。结果猪苓酮B、猪苓酮A、去氢土莫酸、猪苓酸C、去氢茯苓酸和茯苓酸分别在5.79～115.80、1.66～33.20、3.28～65.60、7.07～141.40、1.46～29.20、0.88～17.60μg/mL与峰面积线性关系良好;平均加样回收率分别为98.75%、97.60%、98.23%、99.49%、97.10%、96.81%,RSD值分别为0.75%、1.66%、1.44%、0.90%、1.15%、1.38%。结论本方法简便、准确、重复性好,为威喜丸的质量控制提供了实验依据。
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| 关 键 词： | 威喜丸 猪苓酮B 猪苓酮A 去氢土莫酸 猪苓酸C 去氢茯苓酸 茯苓酸 高效液相色谱 |
| 收稿时间： | 2018/10/31 0:00:00 |
Determination of polyporusterone B, polyporusterone A, dehydrotumulosic acid, polyporenic acid C, dehydropachymic acid and pachymic acid in Weixi Pills by HPLC |
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| ZHAO Dan,WEI Tan-jun,YAN Ming-ying,TANG Qi-rong,HE Ren-d,YUE Jian-dong and LIU Yan-ting.Determination of polyporusterone B, polyporusterone A, dehydrotumulosic acid, polyporenic acid C, dehydropachymic acid and pachymic acid in Weixi Pills by HPLC[J].Drugs & Clinic,2019,34(1):27-30. |
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| Authors: | ZHAO Dan WEI Tan-jun YAN Ming-ying TANG Qi-rong HE Ren-d YUE Jian-dong and LIU Yan-ting |
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| Institution: | Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China,Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China,Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China,Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China,Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China,Dazhou Integrated TCM & amp;Western Medicine Hospital, Dazhou 635000, China and Fujian Institute for Food and Drug Quality Control, Fuzhou 350001, China |
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| Abstract: | |
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| Keywords: | Weixi Pills polyporusterone B polyporusterone A dehydrotumulosic acid polyporenic acid C dehydropachymic acid pachymic acid HPLC |
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