肢体抖动短暂性脑缺血发作的血压变异性研究

目的本研究拟探讨血压变异性(BPV)与肢体抖动短暂性脑缺血发作(LS-TIA)的关系。方法对19例LS-T1A患者(LS-TIA组)、32例TIA患者(TIA组)和33名体检者(对照组)进行动态血压监测,记录24h平均收缩压(24hSBP)、白天平均收缩压(d-SBP)、夜间平均收缩压(n-SBP)、24h平均舒张压(24hDBP)、白天平均舒张压(d-DBP)和夜间平均舒张压(n-DBP),并计算24h收缩压变异性(24h-SBPV)、白天收缩压变异性(chSBPV)、夜间收缩压变异性(n-SBPV)、24h舒张压变异性(24h-DBPV)、白天舒张压变异性(d-DBPV)和夜间舒张压变异性(n-DBPV)。结果与正常对照组比较,LS-TIA组和TIA组的24h-SBP、d-SBP、n-SBP、24h-DBP、d-DBP、n-DBP和脉压指数均显著升高(均P<0.05)。与TIA组比较,LS-TIA组患者脉压指数显著升高(P<0.05)。与对照组比较,LS-TIA组的24h-SBPV、d-SBPV、n-SBPV、24h-DBPV、d-DBPV和n-DBPV显著增高,TIA组的24h-DBPV、d-DBPV和n-DBPV显著增高(P<0.05或P<0.01)。与TIA组比较,LS-TIA组的24h-SBPV、d-SBPV、24h-DBPV和d-DBPV显著增高(均P<0.05)。结论LS-TIA患者较TIA患者BPV升高,BPV升高可能是LS-TIA发病的诱因之一。LS-TIA患者较对照组血压升高,可能是LS-TIA低灌注后代偿性血压升高。LS-TIA较T1A患者脉压指数升高,表明LS-TIA患者血管硬化更为严重。

Blood pressure variability of limb-shaking transient ischemic attack

Objective To investigate the association between blood pressure variability (BPV) and limb-shaking transient ischemic attack (LS-TIA).Methods A total of 19 patients with LS-TIA were enrolled as LS-TIA group, 32 patients with transient ischemic attack (TIA) were enrolled as TIA group, and 33 individuals who underwent physical examination were enrolled as normal control group. Ambulatory blood pressure monitoring was performed for all groups, and mean 24-hour systolic blood pressure (SBP), mean daytime SBP (d-SBP), mean nighttime SBP (n-SBP), mean 24-hour diastolic blood pressure (DBP), mean daytime DBP (d-DBP), and mean nighttime DBP (n-DBP) were measured. The 24-hour systolic blood pressure variability (SBPV), daytime SBPV (d-SBPV), nighttime SBPV (n-SBPV), 24-hour diastolic blood pressure variability (DBPV), daytime DBPV (d-DBPV), and nighttime DBPV (n-DBPV) were calculated.Results Compared with the normal control group, the LS-TIA group and the TIA group had significant increases in 24-hour SBP, d-SBP, n-SBP, 24-hour DBP, d-DBP, n-DBP, and pulse pressure index (all P<0.05). Compared with the TIA group, the LS-TIA group had a significant increase in pulse pressure index (P<0.05). Compared with the normal control group, the LS-TIA group had significant increases in 24-hour SBPV, d-SBPV, n-SBPV, 24-hour DBPV, d-DBPV, and n-DBPV, and the TIA group had significant increases in 24-hour DBPV, d-DBPV, and n-DBPV (P<0.05 or P<0.01). Compared with the TIA group, the LS-TIA group had significant increases in 24-hour SBPV, d-SBPV, 24-hour DBPV, and d-DBPV (all P<0.05).Conclusions Compared with patients with TIA, patients with LS-TIA have an increase in BPV, which may be one of the causes of LS-TIA. Compared with healthy controls, patients with LS-TIA have an increase in blood pressure, which may be compensatory increase in blood pressure after LS-TIA hypoperfusion. Compared with patients with TIA, patients with LS-TIA have an increase in pulse pressure index, indicating that LS-TIA patients have a higher degree of vascular sclerosis.