| APT在胶质瘤假性进展与复发鉴别中的应用 |
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| 引用本文： | 杨粤龙,黄飚.APT在胶质瘤假性进展与复发鉴别中的应用[J].国际医学放射学杂志,2019,42(5):535-538. |
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| 作者姓名： | 杨粤龙 黄飚 |
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| 作者单位： | 广东省医学科学院 广东省人民医院放射科,广州,510080;广东省医学科学院 广东省人民医院放射科,广州,510080 |
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| 基金项目： | 广东省重点领域研发计划项目（2018B030339001） |
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| 摘 要： | 目前，高级别胶质瘤术后常辅以放疗或同步放化疗。治疗后呈现的假性进展与肿瘤复发在常规MRI中表现极为相似，两者在临床上难于鉴别。酰胺质子转移（APT）技术通过检查组织中的酰胺质子含量对鉴别两者有较高的敏感性和特异性。就APT在胶质瘤假性进展与复发鉴别中的应用，以及相比动态磁敏感对比增强灌注加权成像（DSC-PWI）、磁共振波谱成像（MRS）、PET技术的优势予以综述。
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| 关 键 词： | 胶质瘤 随访 复发 假性进展 酰胺质子转移 |
| 收稿时间： | 2018-12-25 |
Differentiating pseudoprogression from recurrence in patients with gliomas using amide proton transfer imaging |
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| YANG Yuelong,HUANG Biao.Differentiating pseudoprogression from recurrence in patients with gliomas using amide proton transfer imaging[J].International Journal of Medical Radiology,2019,42(5):535-538. |
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| Authors: | YANG Yuelong HUANG Biao |
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| Institution: | Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou 510080, China |
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| Abstract: | Currently, radiotherapy or concurrent chemoradiation is often used as an adjunct method in the treatment of patients with high-grade gliomas (HGG) after surgery. Distinguishing treatment-related imaging changes such as pseudoprogression from tumor recurrence is difficult due to extremely similar appearances on conventional MRI. Amide proton transfer (APT) imaging have relatively high sensitivity and specificity to distinguish pseudoprogression from tumor recurrence by examining the content of amide proton in tissue. This paper reviews the APT in differentiating pseudoprogression from recurrence of gliomas and its advantages compared with DSC-PWI, MRS, and PET. |
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| Keywords: | Glioma Follow-up Recurrence Pseudoprogression Amide proton transfer |
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