| 亚慢性吸入甲醛对小鼠抗氧化物酶的影响 |
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| 引用本文： | 张全武,孙少华,王振全,杨迪. 亚慢性吸入甲醛对小鼠抗氧化物酶的影响[J]. 医学争鸣, 2003, 24(23): 2206-2207 |
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| 作者姓名： | 张全武 孙少华 王振全 杨迪 |
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| 作者单位： | 兰州医学院,病理学教研室,甘肃,兰州,730000;兰州医学院,公共卫生系,甘肃,兰州,730000;三门峡市人民医院,河南,三门峡,472000 |
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| 摘 要： | 目的 :通过观察甲醛 (formaldehyde ,FA)对小鼠抗氧化物酶活力的影响 ,探讨其毒性作用机制 .方法 :采用小鼠静式吸入染毒方法 ,观察小鼠全血、心、肝、肺和脑组织中谷胱甘肽过氧化物酶 (glutathioneperoxidase ,GSH Px)和超氧化物歧化酶 (superoxidedismutase,SOD)活力的变化 .结果 :小鼠全血、肝和肺组织中所有染毒剂量组SOD活力显著低于对照组(P <0 .0 5 ,P <0 .0 1 ) ;全血、肝和肺组织中 ,高剂量染毒组GSH Px活力与对照组相比较明显降低 ,差异有显著性 (P <0 .0 5 ,P <0 .0 1 ) .结论 :FA可抑制小鼠全血、肝和肺组织中SOD和GSH Px活力 ,从而使小鼠抗氧化能力降低
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| 关 键 词： | 甲醛 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
| 文章编号： | 1000-2790(2003)23-2206-02 |
| 修稿时间： | 2003-05-02 |
Effects of formaldehyde on activities of antioxidase by subchronic inhalation in mice |
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| ZHANG Quan Wu ,SUN Shao Hua ,WANG Zhen Quan ,YANG Di. Effects of formaldehyde on activities of antioxidase by subchronic inhalation in mice[J]. Negative, 2003, 24(23): 2206-2207 |
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| Authors: | ZHANG Quan Wu SUN Shao Hua WANG Zhen Quan YANG Di |
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| Affiliation: | ZHANG Quan Wu 1,SUN Shao Hua 1,WANG Zhen Quan 2,YANG Di 3 1Department of Pathology,2Department of Public Health,Lanzhou Medial College,Lanzhou 730000,China,3Sanmenxia People's Hospital,Sanmenxia 472000,China |
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| Abstract: | AIM: To explore the toxicity effects of formaldehyde (FA) on the antioxidase in mice and its mechanism. METHODS: Mice were exposed to FA by inspiration in a static total enclosure chamber. After exposure, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) in the blood, heart, liver, lung and brain were observed. RESULTS: Significantly lower activities of SOD in the blood, liver and lung were observed in all dose groups compared with those in negative control group ( P <0.05, P <0.01). The activities of GSH Px in the lung, blood and liver decreased significantly in medium and high dose groups ( P <0.05, P <0.01). CONCLUSION: FA may lower the antioxidase abilities by inhibiting the SOD and GSH Px activities in the blood, liver and lung tissues of mice. |
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| Keywords: | formaldehyde superoxide dismutase glutathione peroxidase |
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