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| 自体外周血干细胞移植治疗非霍奇金淋巴瘤的外周血干细胞动员方案临床分析 | |
| 引用本文： | Huang SY,Liu L,Hao MW,Yin DD,Wu YL,Chen RA,Li GH,Lui Q,Wang JC,He H,Liang YM. 自体外周血干细胞移植治疗非霍奇金淋巴瘤的外周血干细胞动员方案临床分析[J]. 中国实验血液学杂志, 2011, 19(6): 1415-1418 |
| 作者姓名： | Huang SY Liu L Hao MW Yin DD Wu YL Chen RA Li GH Lui Q Wang JC He H Liang YM |
| 作者单位： | 1. 第四军医大学唐都医院血液科,陕西西安,710038 2. 第四军医大学唐都医院传染科,陕西西安,710038 |
| 摘 要： | 本研究比较CEP+G-CSF与CVP+G-CSF动员方案对非霍奇金淋巴瘤(NHL)患者外周血造血干细胞动员采集及造血恢复的效果。回顾性分析我科收治的57例NHL患者。分组采用CEP+G-CSF与CVP+G-CSF动员方案进行外周血干细胞动员采集,并于预处理结束后回输外周血干细胞,分析动员效果、不良反应及自身移植后造血恢复情况。结果表明:动员期间所有患者外周血白细胞(WBC)计数均降至1.0×109/L以下,血小板(Plt)数降至40×109/L以下。57例患者均采集成功,CEP+G-CSF动员方案组采集单个核细胞(MNC)数和CD34+细胞数明显高于CVP+G-CSF动员方案组(p=0.002和p=0.019)。预处理后所有病例均达到骨髓抑制,CEP+G-CSF和CVP+G-CSF动员方案组WBC数恢复到≥1.0×109/L的平均时间分别为11.4和12.3天(p﹥0.05),Plt数恢复到≥50×109/L的平均时间分别为18.6和19.3天(p﹥0.05)。结论:自体外周血干细胞移植治疗NHL疗效显著,CEP或CVP联合G-CSF方案行外周血干细胞动员均安全有效,临床效果满意,CEP+G-CSF方案动员外周血干细胞效果更好。 |
| 关 键 词： | 非霍奇金淋巴瘤 自体外周血干细胞移植 化学治疗 外周血干细胞动员 |
Clinical analysis of peripheral blood stem cell mobilization regimens in autologous transplantation for treating non-Hodgkin's lymphoma |
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| Huang Si-Yong,Liu Li,Hao Miao-Wang,Yin Dan-Dan,Wu Yan-Lan,Chen Ren-An,Li Gou-Hui,Lui Qian,Wang Jing-Cheng,He Hua,Liang Ying-Min. Clinical analysis of peripheral blood stem cell mobilization regimens in autologous transplantation for treating non-Hodgkin's lymphoma[J]. Journal of experimental hematology, 2011, 19(6): 1415-1418 | |
| Authors: | Huang Si-Yong Liu Li Hao Miao-Wang Yin Dan-Dan Wu Yan-Lan Chen Ren-An Li Gou-Hui Lui Qian Wang Jing-Cheng He Hua Liang Ying-Min |
| Affiliation: | HUANG Si-Yong,LIU Li,HAO Miao-Wang,YIN Dan-Dan,WU Yan-LAN1,CHEN Ren-An,LI Gou-Hui,LUI Qian,WANG Jing-Cheng,HE Hua,LIANG Ying-Min Department of Hematology,1Department of Infectious Diseases,Fourth Military Medical University Tangdu Hospital,Xi'an 710038,Shaanxi Province,China |
| Abstract: | The purpose of this study was to compare the efficacy of CEP plus G-CSF and CVP plus G-CSF regimens in the mobilization and collection of peripheral blood hematopoietic stem cells(PBHSC),and in the hematopoietic recovery.57 patients with non-Hodgkin's lymphoma(NHL) underwent autologous PBHSC transplantation were analyzed retrospectively.The PBHSC were mobilized and collected by using CEP plus G-CSF and CVP plus G-CSF respectively,and were retransfused into these NHL patients after preconditioning,then the m... |
| Keywords: | non-Hodgkin's lymphoma autologous peripheral blood stem cell transplantation chemotherapy peripheral blood stem cell mobilization |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |