Achalasia of the anal sphincter |
| |
| Authors: | B. Fadda J. Welskop H. Müntefering W. Meier-Ruge J. Engert |
| |
| Affiliation: | (1) Departemento de Cirurgia Infantil, Hospital E. Deformes, Valparaiso, Chile;(2) Abteilung für Kinderpathologie des Pathologischen Instituts der Johannes-Gutemberg-Universität Langenbeckstrasse 1, D-6500 Mainz, Germany;(3) Division of Neuropathology, Department of Pathology, University of Basle, CH-4003 Basle, Switzerland;(4) Kinderchirurgische Klinik der Ruhruniversität, D-4630 Bochum, Germany |
| |
| Abstract: | ![]()
Enzyme-histotopochemical studies of parasympathetic innervation in the internal anal sphincter muscle of 73 children with anal sphincter achalasia indicated that in Hirschsprung's disease and type B neuronal intestinal dysplasia (NID) the internal sphincter displays a pattern of changes analogous to that seen in the wall of the rectum. In Hirschsprung's disease the internal sphincter is also aganglionic, and its parasympathetic fibres exhibit increased acetylcholinesterase (ACE) activity in NID there is moderately increased ACE activity, with ganglionic neurons embedded singly or in groups in the thick afferent parasympathetic fibers. The innervation defect may be confined to the sphincter, or aganglionosis of the sphincter may be associated with proximal NID.Offprint requests to: J. Welskop |
| |
| Keywords: | Sphincter ani internus Aganglionosis Neuronal intestinal dysplasia (type B) Sphincter achalasia Biopsy diagnosis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
