|
|||||
|
|
| 白细胞-内皮细胞间黏附分子-1基因多态性与2型糖尿病肾病的关系 | |
| 引用本文： | 李谊文,薛惠斌,拓西平.白细胞-内皮细胞间黏附分子-1基因多态性与2型糖尿病肾病的关系[J].西北国防医学杂志,2006,27(1):31-33. |
| 作者姓名： | 李谊文 薛惠斌 拓西平 |
| 作者单位： | 1. 解放军第五医院干部病房,宁夏,银川,750004 2. 上海东方肝胆外科医院基因及病毒治疗实验室 3. 上海长海医院老年病科 |
| 摘 要： | 目的：研究白细胞-内皮细胞间黏附分子-1（LECAM-1）在P213S位点的基因多态性与2型糖尿病肾病的关系。方法：应用聚合酶链反应和限制性内切酶方法检测28～76岁2型糖尿病肾病55例、2型糖尿病非肾病64例和正常对照组112例的LECAM-1基因的多态性。结果：糖尿病肾病组LECAM-1213PP基因型和P等位基因频率显著高于非糖尿病肾病组及对照组（P〈0.05）。结论：LECAM-1基因多态性与2型糖尿病肾病发病有明显的相关性，213PP基因型可能是2型糖尿病肾病的遗传危险因素。 |
| 关 键 词： | 糖尿病肾病 黏附分子 多态性 |
| 文章编号： | 1007-8622（2006）01-0031-03 |
| 收稿时间： | 2005-10-23 |
| 修稿时间： | 2005年10月23 |
Relationship between leukocyte-endothelial cell adhesion molecule(LECAM-1) gene polymorphism and diabetic nephropathy in type 2 diabetes mellitus |
|
| LI Yi-wen,XUE Hui-bin,TUO Xi-ping.Relationship between leukocyte-endothelial cell adhesion molecule(LECAM-1) gene polymorphism and diabetic nephropathy in type 2 diabetes mellitus[J].Medical Journal of National Defending Forces in Northwest China,2006,27(1):31-33. | |
| Authors: | LI Yi-wen XUE Hui-bin TUO Xi-ping |
| Abstract: | Objective:To study the relationship between genetic polymorphism in leukocyte-endothelial cell(adhesion) molecule(LECAM-1) and diabetic nephropathy in patients with type 2 diabetes mellitus.Methods: The frequency of LECAM-1 P213S genotype was determined by polymerase chain reaction(PCR) and restriction fragment length polymorphism assay in 55 patients with diabetic nephropathy,64 type 2 diabetes mellitus patients without diabetic nephropathy,and 112 healthy control individuals.Results: The frequency of LECAM-1 213PP genotype and P allele in patients with nephropathy was significantly higher than those in patients without(nephropathy) and in healthy control individuals(P <0.05).Conclusion: LECAM-1 gene polymorphism is(associated) with diabetic nephropathy in patients with type 2 diabetes mellitus.213PP genotype is a genetic risk(factor) for the development of nephropathy in type 2 diabetes mellitus. |
| Keywords: | LECAM-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |