Two patterns of firing in human neocortical neurons

Intracellular recordings were made in slices of human neocortex removed for surgical treatment of epilepsy. In response to prolonged suprathreshold current injection, regular spiking neurons (67.5% of sample) responded by repetitive firing throughout the stimulus from all membrane potentials. Bursting neurons (32.5% of sample) responded with a burst of 2–3 spikes which rode upon a voltage-dependent slow depolarization. Bursting behavior was only observed from membrane potentials more negative than −65 mV.