端粒缩短在鼻咽癌发病作用中的研究 Telomere shortening in the pathogenesis of nasopharyngeal carcinoma]期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

端粒缩短在鼻咽癌发病作用中的研究

摘要：
关键词：	鼻咽癌端粒 DNA分子杂交发病机理
Telomere shortening in the pathogenesis of nasopharyngeal carcinoma]

Zhong Wen,Jian-Yun Xiao,Meng-He Guo. Telomere shortening in the pathogenesis of nasopharyngeal carcinoma][J]. Journal of First Military Medical University, 2002, 22(4): 329-330

Authors:	Zhong Wen Jian-Yun Xiao Meng-He Guo

Affiliation:	Department of Otolaryngology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.

Abstract:	OBJECTIVE: To explore the role of telomere shortening in the pathogenesis of nasopharyngeal carcinoma (NPC). METHODS: Southern blotting was employed to determine the mean telomere length (MTL) in 42 tumor samples and 15 samples of the tissues adjacent to the tumors obtained from 42 NPC patients, along with the tissue specimens from 17 patients with chronic nasopharyngitis. RESULTS: In NPC tissues, the length of the MTL was 4.5+/-2.3 kb, obviously shorter than those of the MTL in tissues adjacent to the tumor 14.6+/-2.8 kb and in chronic nasopharyngitis 15.8+/-3.1 kb. CONCLUSION: Telomere shortening may play an important role in the pathogenesis of nasopharyngeal epithelium cell malignancies.

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