复方颈舒片药效初步研究

目的:对复方颈舒片(川芎、白芷、天麻、狗脊、杭菊花)的药理作用进行研究。方法:利用角叉菜胶性足跖肿胀实验和棉球肉芽肿实验,观察该药对不同炎症模型的作用;测量该药对正常以及坐骨神经结扎大鼠模型机械性痛阈的影响;利用斜板实验观察该药对坐骨神经结扎大鼠四肢肌力的总体影响。结果:该药明显降低大鼠角叉菜胶致炎模型的关节肿胀度、棉球肉芽肿的湿重和干重,提高正常大鼠的痛阈,使坐骨神经结扎大鼠模型健患侧痛阈变化百分率降低、斜板实验角度上升速度明显加快。结论:该药具有明显的抗炎、镇痛作用,还能明显改善由于神经卡压造成的运动功能障碍。

Pharmacodynamical research of Fufang Jingshu Tablet

AIM: To research Fufang Jingshu Tablet's(Rhizoma Chuanxiong,Radix Angelicae Dahuricae,Rhizoma Gastrodiae,Rhizoma Cibotii,Flos Chrysanthemi) pharmacological effect. METHODS: We used carrageenan-induced rat foot edema model and cotton pellet-induced granuloma model to observe the tablet's effect on inflammation,used analgesymeter to assess normal rats' and sciatic-nerve-stem-ligation rats' mechanical withdrawal thresholds,used inclined plane methods to assess the tablet's effect on general extremity strength of sciatic-nerve-stem-ligation model. RESULTS: The tablet could obviously reduce carrageenan-induced foot edema and cotton pellet-induced granuloma,elevate normal rats' mechanical withdrawal thresholds and decrease percent change of mechanical threshold of ipsilateral hind paws,elevate sciatic-nerve-stem-ligation rats' staying angle on inclined plane. CONCLUSION: Fufang Jiangshu Tablet has significant anti-inflammatory and analgesic effects. Furthermore it can improve the movement disfunction stemed from nerve compression significantly.