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| 武穴市慢性乙型肝炎患者IL-1β（＋3953C／T）位点基因多态性调查分析 | |
| 引用本文： | 蒋海平,朱丽. 武穴市慢性乙型肝炎患者IL-1β（＋3953C／T）位点基因多态性调查分析[J]. 公共卫生与预防医学, 2009, 20(1): 16-18 |
| 作者姓名： | 蒋海平 朱丽 |
| 作者单位： | 湖北省武穴市第一人民医院; |
| 摘 要： | 目的调查湖北省武穴地区慢性乙型肝炎患者白细胞介素-1β基因（IL-1β）第5号外显子（＋3953C／T）位点基因多态性的分布及其相关性。方法采用聚合酶链反应一限制性片段长度多态性的分析方法，检测了360例慢性乙型肝炎患者和340例健康对照者IL-1β（＋3953C／T）位点基因多态性，计算并分析其基因型和等位基因频率。结果在病例组和健康对照组，IL-1β（＋3953C／T）位点基因型的分布以CC型最为多见，CT型次之，没有发现TT型，C等位基因频率明显偏高，T等位基因频率明显偏低；在不同性别之间无显著性差异（P〉0．05）；其基因型及等位基因的分布在病例组和对照组间无显著性差异（P〉0．05）。结论在湖北省武穴地区，IL-1β（＋3953C／T）位点碱基突变率极低，其基因型及等位基因型的分布不存在性别之间的区别，与慢性乙型肝炎病程不存在相关性。 |
| 关 键 词： | 慢性乙型肝炎 白细胞介素-1β 基因 多态性 |
Patients with Chronic Hepatitis B in Wuxue Region, Hubei Province |
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| JIANG Hai-pin,ZHU Li. Patients with Chronic Hepatitis B in Wuxue Region, Hubei Province[J]. Journal of Public Health and Preventive Medicine, 2009, 20(1): 16-18 | |
| Authors: | JIANG Hai-pin ZHU Li |
| Affiliation: | JIANG Hai-pin,ZHU Li.Department of Laboratory Science,The Wuxue First Renmin Hospital of Hubei Province,Hubei,Wuxue 435400,China |
| Abstract: | Objective To investigate the distribution of gene polymorphism in the fifth exon of interleukin-1 beta at position +3953 in patients with chronic hepatitis B in Wuxue region,Hubei province and their correlation.Methods The IL-1B(+3953 C/T) polymorphism was detected by polymerase chain reaction and restriction fragment length polymorphisms methods in 360 patients with chronic hepatitis B and 340 healthy controls,then genotype and allele frequencies were calculated and analyzed.Results In patients and control... |
| Keywords: | Chronic hepatitis B Interleukin-1 beta Gene Polymorphism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |