谷氨酰胺强化肠内营养支持对老年晚期胃癌患者营养指标、免疫功能和生活质量的作用分析

目的分析谷氨酰胺强化肠内营养支持对老年晚期胃癌患者营养指标、免疫功能和生活质量的作用。方法96例老年晚期胃癌患者,按照干预方法不同分为对照组和观察组,每组48例。对照组患者应用以肠内营养混悬液(TPF)为主的常规化营养支持方案进行干预,观察组患者应用TPF+谷氨酰胺营养支持方案进行干预。比较两组患者干预前后营养指标红细胞(RBC)、白蛋白(ALB)、前白蛋白(PA)]、免疫功能指标免疫球蛋白(Ig)E、IgA、IgM]水平以及干预后的生活质量。结果干预后,观察组患者PA(196.35±15.24)mg/L、ALB(33.45±3.12)g/L、RBC(4.33±1.02)×10¹²/L均高于对照组的(173.26±16.24)mg/L、(28.53±3.03)g/L、(3.90±0.98)×10¹²/L,差异均具有统计学意义(P<0.05)。观察组患者干预后的精神健康、情绪角色、社会功能、活力水平、总体健康、肢体疼痛、躯体角色、躯体功能评分均高于对照组,差异均具有统计学意义(P<0.05)。干预后,观察组患者IgM、IgA、IgG水平分别为(1.66±0.63)、(3.17±1.02)、(11.36±1.74)g/L,均高于对照组的(1.32±0.77)、(2.43±0.96)、(9.22±1.03)g/L,差异均具有统计学意义(P<0.05)。结论针对晚期胃癌患者应用谷氨酰胺强化肠内营养支持,有助于改善其机体免疫功能及营养指标,同时也可提升患者生活质量,值得进一步于临床推广和应用。

Effects of glutamine enhanced enteral nutrition support on nutritional indicators,immune function and quality of life in elderly patients with advanced gastric cancer

Objective To analyze the effects of glutamine enhanced enteral nutrition support on nutritional indicators,immune function and quality of life in elderly patients with advanced gastric cancer.Methods A total of 96 elderly patients with advanced gastric cancer were divided into control group and observation group according to different intervention methods,with 48 cases in each group.Patients in the control group received routine nutritional support of enteral nutrition suspension(TPF),and patients in the observation group received TPF+glutamine nutritional support.The nutritional indicatorsred blood cell(RBC),albumin(ALB),prealbumin(PA)]before and after intervention,immune function indicatorsimmunoglobulin(Ig)E,IgA,IgM]levels and quality of life after intervention were compared between the two groups.Results After intervention,the PA(196.35±15.24)mg/L,ALB(33.45±3.12)g/L and RBC(4.33±1.02)×10¹²/L of the observation group were all higher than(173.26±16.24)mg/L,(28.53±3.03)g/L and(3.90±0.98)×10¹²/L of the control group,and the difference was statistically significant(P<0.05).After intervention,the mental health,emotional role,social function,vitality level,general health,limb pain,physical role,physical function score of the observation group were all higher than those of the control group,and the difference was statistically significant(P<0.05).After intervention,the levels of IgM,IgA and IgG of the observation group were(1.66±0.63),(3.17±1.02)and(11.36±1.74)g/L,which were all higher than(1.32±0.77),(2.43±0.96)and(9.22±1.03)g/L of the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with advanced gastric cancer,glutamine enhanced enteral nutrition support is helpful to improve immune function indicators and the quality of life of the patients.This method is worthy of further promotion and application in clinic.