Language and brain volumes in children with epilepsy |
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| Authors: | Rochelle Caplan Jennifer Levitt Prabha Siddarth Keng Nei Wu Suresh Gurbani W. Donald Shields Raman Sankar |
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| Affiliation: | 1. Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, Second University of Naples, Via Sergio Pansini 5, 80131 Naples, Italy;2. Child Neurology, Pediatric Headache & Sleep Disorders Centre, Chair of Pediatrics, NESMOS Department, Faculty of Medicine and Psychology, “Sapienza University”, Via Di Grottarossa 1035-1039, 00189 Rome, Italy;3. Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK;4. Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Via Conte Ruggiero 73, 94018 Troina (EN), Italy;1. Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, UK;2. Epilepsy Society, Chalfont St Peter, Buckinghamshire, UK;3. University College Hospital, London, UK;1. Comprehensive Pediatric Epilepsy Program, Children''s National Medical Center, Washington, DC, USA;2. Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA;3. Department of Psychiatry and Behavioral Sciences, The George Washington University, Washington, DC, USA;4. Department of Pediatrics and Neurology, The George Washington University, Washington, DC, USA;5. Department of Speech, Language, and Hearing Sciences, The George Washington University, Washington, DC, USA;1. Department of Psychology, The Hospital for Sick Children, Toronto, Canada;2. Department of Psychology, University of Toronto Mississauga, Mississauga, Canada;3. Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada |
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| Abstract: | ![]()
In this study the relationship between language skill and frontotemporal volumes was compared in 69 medically treated subjects with epilepsy and 34 healthy children, aged 6.1–16.6 years. Also, whether patients with linguistic deficits had abnormal volumes and atypical associations between volumes and language skills in these brain regions was determined. The children underwent language testing and MRI scans at 1.5 T. Brain tissue was segmented and frontotemporal volumes were computed. Higher mean language scores were significantly associated with larger inferior frontal gyrus, temporal lobe, and posterior superior temporal gyrus gray matter volumes in the epilepsy group and in the children with epilepsy with average language scores. Increased total brain and dorsolateral prefrontal gray and white matter volumes, however, were associated with higher language scores in the healthy controls. Within the epilepsy group, linguistic deficits were related to smaller anterior superior temporal gyrus gray matter volumes and there was a negative association between language scores and dorsolateral prefrontal gray matter volumes. These findings demonstrate abnormal development of language-related brain regions, and imply differential reorganization of brain regions subserving language in children with epilepsy with normal linguistic skills and in those with impaired language. |
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